Abstract Chronic Lymphocytic Leukemia (CLL) is a malignancy of mature B lymphocytes
which are highly dependent on interactions with the tissue microenvironment for their …

The membrane proteins CD38 and CD157 belong to an evolutionarily conserved family of
enzymes that play crucial roles in human physiology. Expressed in distinct patterns in most …

Chronic lymphocytic leukaemia (CLL) is the most common leukaemia among the adults in
the Western World. CLL (and the corresponding nodal entity small lymphocytic lymphoma …

Over the last decade, the active role of the microenvironment in the pathogenesis of B cell
lymphomas has been recognized, delivering signals that favor clonal expansion and drug …

This review highlights a decade of investigations into the role of CD38 in CLL. CD38 is
accepted as a dependable marker of unfavorable prognosis and as an indicator of activation …

Chronic lymphocytic leukaemia is the commonest form of leukaemia in Europe and North
America, and mainly, though not exclusively, affects older individuals. It has a very variable …

Intrinsic factors such as genetic lesions, anti-apoptotic proteins, and aberrant signaling
networks within leukemia cells have long been the main focus of chronic lymphocytic …

Leukemia-cell expression of ZAP-70, CD38, or unmutated immunoglobulin heavy chain
variable region genes (U-IGHV) each is associated with aggressive disease in patients with …

Abstract Cluster of differentiation 38 (CD38) is a multifunctional extracellular enzyme on the
cell surface with NADase and cyclase activities. CD38 is not only expressed in human …

Predictors of chronic lymphocytic leukaemia (CLL) transformation to Richter syndrome (RS)
are not established and were investigated in 185 consecutive CLL cases. Actuarial …