[HTML][HTML] Microenvironment interactions and B-cell receptor signaling in Chronic Lymphocytic Leukemia: Implications for disease pathogenesis and treatment
E Ten Hacken, JA Burger - Biochimica et Biophysica Acta (BBA)-Molecular …, 2016 - Elsevier
Abstract Chronic Lymphocytic Leukemia (CLL) is a malignancy of mature B lymphocytes
which are highly dependent on interactions with the tissue microenvironment for their …
which are highly dependent on interactions with the tissue microenvironment for their …
Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology
F Malavasi, S Deaglio, A Funaro… - Physiological …, 2008 - journals.physiology.org
The membrane proteins CD38 and CD157 belong to an evolutionarily conserved family of
enzymes that play crucial roles in human physiology. Expressed in distinct patterns in most …
enzymes that play crucial roles in human physiology. Expressed in distinct patterns in most …
Chronic lymphocytic leukaemia
L Scarfò, AJM Ferreri, P Ghia - Critical reviews in oncology/hematology, 2016 - Elsevier
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia among the adults in
the Western World. CLL (and the corresponding nodal entity small lymphocytic lymphoma …
the Western World. CLL (and the corresponding nodal entity small lymphocytic lymphoma …
The microenvironment in chronic lymphocytic leukemia (CLL) and other B cell malignancies: insight into disease biology and new targeted therapies
JA Burger, JG Gribben - Seminars in cancer biology, 2014 - Elsevier
Over the last decade, the active role of the microenvironment in the pathogenesis of B cell
lymphomas has been recognized, delivering signals that favor clonal expansion and drug …
lymphomas has been recognized, delivering signals that favor clonal expansion and drug …
CD38 and chronic lymphocytic leukemia: a decade later
F Malavasi, S Deaglio, R Damle… - Blood, The Journal …, 2011 - ashpublications.org
This review highlights a decade of investigations into the role of CD38 in CLL. CD38 is
accepted as a dependable marker of unfavorable prognosis and as an indicator of activation …
accepted as a dependable marker of unfavorable prognosis and as an indicator of activation …
Chronic lymphocytic leukaemia
G Dighiero, TJ Hamblin - The Lancet, 2008 - thelancet.com
Chronic lymphocytic leukaemia is the commonest form of leukaemia in Europe and North
America, and mainly, though not exclusively, affects older individuals. It has a very variable …
America, and mainly, though not exclusively, affects older individuals. It has a very variable …
Nurture versus nature: the microenvironment in chronic lymphocytic leukemia
JA Burger - Hematology 2010, the American Society of …, 2011 - ashpublications.org
Intrinsic factors such as genetic lesions, anti-apoptotic proteins, and aberrant signaling
networks within leukemia cells have long been the main focus of chronic lymphocytic …
networks within leukemia cells have long been the main focus of chronic lymphocytic …
Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia
LZ Rassenti, S Jain, MJ Keating… - Blood, The Journal …, 2008 - ashpublications.org
Leukemia-cell expression of ZAP-70, CD38, or unmutated immunoglobulin heavy chain
variable region genes (U-IGHV) each is associated with aggressive disease in patients with …
variable region genes (U-IGHV) each is associated with aggressive disease in patients with …
[HTML][HTML] CD38: An important regulator of T cell function
W Li, L Liang, Q Liao, Y Li, Y Zhou - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Abstract Cluster of differentiation 38 (CD38) is a multifunctional extracellular enzyme on the
cell surface with NADase and cyclase activities. CD38 is not only expressed in human …
cell surface with NADase and cyclase activities. CD38 is not only expressed in human …
Biological and clinical risk factors of chronic lymphocytic leukaemia transformation to Richter syndrome
Predictors of chronic lymphocytic leukaemia (CLL) transformation to Richter syndrome (RS)
are not established and were investigated in 185 consecutive CLL cases. Actuarial …
are not established and were investigated in 185 consecutive CLL cases. Actuarial …