Seco B-Type Oligomers from Pinus massoniana Expand the Procyanidin Chemical Space and Exhibit Dental Bioactivity

B Zhou, Y Alania, M Reis, SX Jing… - Journal of natural …, 2022 - ACS Publications
Investigation of a pine bark extract for bioactive proanthocyanidin oligomers resulted in the
isolation of structurally related dimeric seco B-type procyanidin derivatives, 1–5. This …

Unveiling structure–activity relationships of proanthocyanidins with dentin collagen

M Reis, B Zhou, Y Alania, AA Leme-Kraus, S Jing… - Dental Materials, 2021 - Elsevier
Objective To elucidate the structure–activity relationships (SARs) of proanthocyanidins
(PACs) with type I collagen using sixteen chemically defined PACs with degree of …

B-type Proanthocyanidins with Dentin Biomodification Activity from Cocoa (Theobroma cacao)

SX Jing, M Reis, Y Alania, JB McAlpine… - Journal of agricultural …, 2022 - ACS Publications
To enable translational studies, a scalable preparative isolation scheme was developed for
underivatized cocoa (Theobroma cacao) proanthocyanidins (PACs), affording six all-B-type …

Linderanidins A–F: Rare oligomeric flavonoids with an unusual C-3–C-4 linkage from the roots of Lindera erythrocarpa and their inhibitory activities on autophagy

B Ryu, EJ Park, TP Doan, HM Cho, JE Ponce-Zea… - Phytochemistry, 2023 - Elsevier
Autophagy is a crucial process for maintaining cellular homeostasis by degrading and
recycling unnecessary or damaged cellular components. In the process of exploring …

NMR-Based Quantum Mechanical Analysis Builds Trust and Orthogonality in Structural Analysis: The Case of a Bisdesmosidic Triglycoside as Withania somnifera …

S Bhavaraju, D Taylor, M Niemitz… - Journal of natural …, 2021 - ACS Publications
The present study demonstrates the relationship between conventional and quantum
mechanical (QM) NMR spectroscopic analyses, shown here to assist in building a …

Changes to dentin extracellular matrix following treatment with plant-based polyphenols

H Omar, F Gao, H Yoo, O Bim Jr, C Garcia… - Journal of the …, 2022 - Elsevier
This study investigated whether treatment with plant-based polyphenols (PB–P) affected the
biochemical and/or biomechanical properties of dentin extracellular matrix (ECM). Three PB …

Proanthocyanidin block arrays (PACBAR) for comprehensive capture and delineation of proanthocyanidin structures

S Jing, WE Zeller, D Ferreira, B Zhou… - Journal of agricultural …, 2020 - ACS Publications
Proanthocyanidins (PACs) are near-ubiquitous and chemically complex metabolites,
prototypical of higher plants. Their roles in food/feed/nutrition and ethnomedicine are widely …

Unprecedented Benzoquinone Motifs Reveal Post-Oligomerizational Modification of Proanthocyanidins

SX Jing, D Ferreira, P Pandey, LL Klein… - The Journal of …, 2023 - ACS Publications
Proanthocyanidins (PACs) are complex flavan-3-ol polymers with stunning chemical
complexity due to oxygenation patterns, oxidative phenolic ring linkages, and intricate …

Chemical Transformation of B-to A-type Proanthocyanidins and 3D Structural Implications

SX Jing, CM McDermott, PL Flanders… - Journal of Natural …, 2024 - ACS Publications
In nature, proanthocyanidins (PACs) with A-type linkages are relatively rare, likely due to
biosynthetic constraints in the formation of additional ether bonds to be introduced into the …

Spray treatment of leaves with Fe2+ promotes procyanidin biosynthesis by upregulating the expression of the F3H and ANS genes in red rice grains (Oryza sativa L.)

Y He, Y Luo, Q Wang, Y Sun, N Duan, Z Chen… - Journal of Cereal …, 2021 - Elsevier
Red rice (RR) is bred for the high-quality proanthocyanidins (PAs) deposition and
colouration in the pericarp, which contribute to its potential as a functional food ingredient …