An update of epigenetic drugs for the treatment of cancers and brain diseases: a comprehensive review

Z Sahafnejad, S Ramazi, A Allahverdi - Genes, 2023 - mdpi.com
Epigenetics has long been recognized as a significant field in biology and is defined as the
investigation of any alteration in gene expression patterns that is not attributed to changes in …

[HTML][HTML] Upstream and downstream regulators of Klotho expression in chronic kidney disease

SS Li, M Sheng, ZY Sun, Y Liang, LX Yu, QF Liu - Metabolism, 2023 - Elsevier
Klotho is a critical protein that protects the kidney. Klotho is severely downregulated in
chronic kidney disease (CKD), and its deficiency is implicated in the pathogenesis and …

MLCPP 2.0: an updated cell-penetrating peptides and their uptake efficiency predictor

B Manavalan, MC Patra - Journal of Molecular Biology, 2022 - Elsevier
Cell-penetrating peptides (CPPs) translocate into the cell as various biologically active
conjugates and possess numerous biomedical applications. Several machine learning …

Crossing epigenetic frontiers: the intersection of novel histone modifications and diseases

W Yao, X Hu, X Wang - Signal Transduction and Targeted Therapy, 2024 - nature.com
Histone post-translational modifications (HPTMs), as one of the core mechanisms of
epigenetic regulation, are garnering increasing attention due to their close association with …

Epigenetic regulation in lung cancer

S Ramazi, M Dadzadi, Z Sahafnejad, A Allahverdi - MedComm, 2023 - Wiley Online Library
Lung cancer is indeed a major cause of cancer‐related deaths worldwide. The development
of tumors involves a complex interplay of genetic, epigenetic, and environmental factors …

Introduction to epigenetics

N Singla, R Thapa, R Kulshrestha, AA Bhat… - Targeting epigenetics in …, 2023 - Springer
Epigenetics is the study of inherited variations in gene expression that do not involve
changes to DNA sequences. Over 200 unique cell types in a human adult have a nearly …

[HTML][HTML] Epigenetic Modifications of Hormonal Signaling Pathways in Plant Drought Response and Tolerance for Sustainable Food Security

C Kaya, F Uğurlar, IDS Adamakis - International Journal of Molecular …, 2024 - mdpi.com
Drought significantly challenges global food security, necessitating a comprehensive
understanding of plant molecular responses for effective mitigation strategies. Epigenetic …

Epigenetics and plant hormone dynamics: a functional and methodological perspective

J Rudolf, L Tomovicova, K Panzarova… - Journal of …, 2024 - academic.oup.com
Plant hormones, pivotal regulators of plant growth, development, and response to
environmental cues, have recently emerged as central modulators of epigenetic processes …

Mechanism and therapeutic opportunities of histone modifications in chronic liver disease

Q Cai, C Gan, C Tang, H Wu, J Gao - Frontiers in Pharmacology, 2021 - frontiersin.org
Chronic liver disease (CLD) represents a global health problem, accounting for the heavy
burden of disability and increased health care utilization. Epigenome alterations play an …

DNA Methylation in the Fields of Prenatal Diagnosis and Early Detection of Cancers

F Coppedè, U Bhaduri, A Stoccoro, V Nicolì… - International Journal of …, 2023 - mdpi.com
The central objective of the metamorphosis of discovery science into biomedical
applications is to serve the purpose of patients and curtail the global disease burden. The …