[HTML][HTML] TOP mRNPs: molecular mechanisms and principles of regulation
E Cockman, P Anderson, P Ivanov - Biomolecules, 2020 - mdpi.com
The cellular response to changes in the surrounding environment and to stress requires the
coregulation of gene networks aiming to conserve energy and resources. This is often …
coregulation of gene networks aiming to conserve energy and resources. This is often …
Controversies around the function of LARP1
The RNA-binding protein LARP1 has generated interest in recent years for its role in the
mTOR signalling cascade and its regulation of terminal oligopyrimidine (TOP) mRNA …
mTOR signalling cascade and its regulation of terminal oligopyrimidine (TOP) mRNA …
Short poly (A) tails are protected from deadenylation by the LARP1–PABP complex
Deadenylation generally constitutes the first and pivotal step in eukaryotic messenger RNA
decay. Despite its importance in posttranscriptional regulations, the kinetics of …
decay. Despite its importance in posttranscriptional regulations, the kinetics of …
mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1
LARP1 is a key repressor of TOP mRNA translation. It binds the m7Gppp cap moiety and the
adjacent 5′ TOP motif of TOP mRNAs, thus impeding the assembly of the eIF4F complex …
adjacent 5′ TOP motif of TOP mRNAs, thus impeding the assembly of the eIF4F complex …
[HTML][HTML] Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in translation
Target of rapamycin (TOR) is a protein kinase that coordinates eukaryotic metabolism. In
mammals, TOR specifically promotes translation of ribosomal protein (RP) mRNAs when …
mammals, TOR specifically promotes translation of ribosomal protein (RP) mRNAs when …
[HTML][HTML] mTOR-and LARP1-dependent regulation of TOP mRNA poly (A) tail and ribosome loading
K Ogami, Y Oishi, K Sakamoto, M Okumura… - Cell reports, 2022 - cell.com
Translation of 5′ terminal oligopyrimidine (TOP) mRNAs encoding the protein synthesis
machinery is strictly regulated by an amino-acid-sensing mTOR pathway. However, its …
machinery is strictly regulated by an amino-acid-sensing mTOR pathway. However, its …
Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation
A Galloway, A Kaskar, D Ditsova, A Atrih… - Nucleic acids …, 2021 - academic.oup.com
The m7G cap is ubiquitous on RNAPII-transcribed RNA and has fundamental roles in
eukaryotic gene expression, however its in vivo role in mammals has remained unknown …
eukaryotic gene expression, however its in vivo role in mammals has remained unknown …
[HTML][HTML] Subcellular mRNA localization regulates ribosome biogenesis in migrating cells
Translation of ribosomal protein-coding mRNAs (RP-mRNAs) constitutes a key step in
ribosome biogenesis, but the mechanisms that modulate RP-mRNA translation in …
ribosome biogenesis, but the mechanisms that modulate RP-mRNA translation in …
Structural basis of 3′-end poly (A) RNA recognition by LARP1
G Kozlov, S Mattijssen, J Jiang, S Nyandwi… - Nucleic Acids …, 2022 - academic.oup.com
La-related proteins (LARPs) comprise a family of RNA-binding proteins involved in a wide
range of posttranscriptional regulatory activities. LARPs share a unique tandem of two RNA …
range of posttranscriptional regulatory activities. LARPs share a unique tandem of two RNA …
RNA localization mechanisms transcend cell morphology
RNA molecules are localized to specific subcellular regions through interactions between
RNA regulatory elements and RNA binding proteins (RBPs). Generally, our knowledge of …
RNA regulatory elements and RNA binding proteins (RBPs). Generally, our knowledge of …