In the middle of the 20th century, it was postulated that degradation of intracellular proteins
is a stochastic process. More than fifty years of intense studies have finally proven that …

Intrinsically disordered myelin basic protein (MBP) is one of the key autoantigens in
autoimmune neurodegeneration and multiple sclerosis particularly. MBP is highly positively …

Recent findings indicate that the ubiquitin–proteasome system is involved in the
pathogenesis of cancer as well as autoimmune and several neurodegenerative diseases …

Multiple sclerosis and migraine with aura are clinically correlated and both show imaging
changes suggestive of myelin disruption. Furthermore, cortical myelin loss in the cuprizone …

ABSTRACT A majority of thousands of intracellular mammalian proteins are recognized by
proteasome only being conjugated with ubiquitin (Ub), representing a universal degradation …

Astrocytes are considered to be an important contributor to central nervous system (CNS)
disorders, particularly multiple sclerosis. The transcriptome of these cells is greatly affected …

Purpose MHC class I presentation of peptides allows T cells to survey the cytoplasmic
protein milieu of host cells. During infection, presentation of self peptides is, in part, replaced …

Induction of the detoxifying enzyme heme oxygenase‐1 (HO‐1) is a critical protective host
response to cellular injury associated with inflammation and oxidative stress. We previously …

Proteins with extended polyglutamine regions are associated with several
neurodegenerative disorders, including Huntington's disease. Intracellular proteolytic …

Objective: The 26S proteasome is a unique multicatalytic proteinase complex, which,
together with the ubiquitination system, provides controlled degradation of most intracellular …