Peroxisome proliferator-activated receptor-α (PPARα), PPARδ and PPARγ are transcription
factors that regulate gene expression following ligand activation. PPARα increases cellular …

Growth and differentiation factor 15 (GDF15) belongs to the transforming growth factor-β
(TGF-β) superfamily of proteins. Glial-derived neurotrophic factor (GDNF) family receptor α …

Postnatal maturation of cardiomyocytes is characterized by a metabolic switch from
glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle …

Background: The human heart primarily metabolizes fatty acids, and this decreases as
alternative fuel use rises in heart failure with reduced ejection fraction (HFrEF). Patients with …

Birth presents a metabolic challenge to cardiomyocytes as they reshape fuel preference
from glucose to fatty acids for postnatal energy production,. This adaptation is triggered in …

Current methods to differentiate cardiomyocytes from human pluripotent stem cells (PSCs)
inadequately recapitulate complete development and result in PSC-derived cardiomyocytes …

Zebrafish and mammalian neonates possess robust cardiac regeneration via the induction
of endogenous cardiomyocyte (CM) proliferation, but adult mammalian hearts have very …

Aims Metabolic switching during heart development contributes to postnatal cardiomyocyte
(CM) cell cycle exit and loss of regenerative capacity in the mammalian heart. Metabolic …

Parkinson's disease (PD) is a common age-related neurodegenerative disorder whose
pathogenesis is not completely understood. Mitochondrial dysfunction and increased …

Background: The regenerative capacity of the heart after myocardial infarction is limited. Our
previous study showed that ectopic introduction of 4 cell cycle factors (4F; CDK1 [cyclin …