Pain-related cortico-limbic plasticity and opioid signaling
V Neugebauer, P Presto, V Yakhnitsa, N Antenucci… - …, 2023 - Elsevier
Neuroplasticity in cortico-limbic circuits has been implicated in pain persistence and pain
modulation in clinical and preclinical studies. The amygdala has emerged as a key player in …
modulation in clinical and preclinical studies. The amygdala has emerged as a key player in …
[HTML][HTML] Disentangling the identity of the zona incerta: a review of the known connections and latest implications
The zona incerta (ZI) is a subthalamic region composed by loosely packed neurochemically
mixed neurons, juxtaposed to the main ascending and descending bundles. The extreme …
mixed neurons, juxtaposed to the main ascending and descending bundles. The extreme …
The parabrachial to central amygdala pathway is critical to injury-induced pain sensitization in mice
JM Torres-Rodriguez, TD Wilson, S Singh… - …, 2024 - nature.com
The spino-ponto-amygdaloid pathway is a major ascending circuit relaying nociceptive
information from the spinal cord to the brain. Potentiation of excitatory synaptic transmission …
information from the spinal cord to the brain. Potentiation of excitatory synaptic transmission …
Parabrachial Calca neurons drive nociplasticity
Pain that persists beyond the time required for tissue healing and pain that arises in the
absence of tissue injury, collectively referred to as nociplastic pain, are poorly understood …
absence of tissue injury, collectively referred to as nociplastic pain, are poorly understood …
Reattribution to mind-brain processes and recovery from chronic back pain: a secondary analysis of a randomized clinical trial
Importance In primary chronic back pain (CBP), the belief that pain indicates tissue damage
is both inaccurate and unhelpful. Reattributing pain to mind or brain processes may support …
is both inaccurate and unhelpful. Reattributing pain to mind or brain processes may support …
Cell type-specific dissection of sensory pathways involved in descending modulation
Decades of research have suggested that stimulation of supraspinal structures, such as the
periaqueductal gray (PAG) and rostral ventromedial medulla (RVM), inhibits nocifensive …
periaqueductal gray (PAG) and rostral ventromedial medulla (RVM), inhibits nocifensive …
[HTML][HTML] Projections from the rostral zona incerta to the thalamic paraventricular nucleus mediate nociceptive neurotransmission in mice
FL Wu, SH Chen, JN Li, LJ Zhao, XM Wu, J Hong… - Metabolites, 2023 - mdpi.com
Zona incerta (ZI) is an integrative subthalamic region in nociceptive neurotransmission.
Previous studies demonstrated that the rostral ZI (ZIR) is an important gamma–aminobutyric …
Previous studies demonstrated that the rostral ZI (ZIR) is an important gamma–aminobutyric …
Zona incerta distributes a broad movement signal that modulates behavior
The zona incerta is a subthalamic nucleus made up mostly of GABAergic neurons. It has
wide-ranging inputs and outputs and is believed to have many integrative functions that link …
wide-ranging inputs and outputs and is believed to have many integrative functions that link …
[HTML][HTML] Exercise therapy for chronic pain: How does exercise change the limbic brain function?
E Senba, K Kami - Neurobiology of Pain, 2023 - Elsevier
We are exposed to various external and internal threats which might hurt us. The role of
taking flexible and appropriate actions against threats is played by “the limbic system” and at …
taking flexible and appropriate actions against threats is played by “the limbic system” and at …
[HTML][HTML] The parabrachial to central amygdala circuit is a key mediator of injury-induced pain sensitization
JM Torres-Rodriguez, TD Wilson, S Singh, S Chaudhry… - bioRxiv, 2023 - ncbi.nlm.nih.gov
The spino-ponto-amygdaloid pathway is a major ascending circuit relaying nociceptive
information from the spinal cord to the brain. Potentiation of excitatory synaptic transmission …
information from the spinal cord to the brain. Potentiation of excitatory synaptic transmission …