Rho GTPases are well known for their roles in regulating cell migration, and also contribute
to a variety of other cellular responses. They are subdivided into 2 groups: typical and …

Formin proteins were recognized as effectors of Rho GTPases some 15 years ago. They
contribute to different cellular actin cytoskeleton structures by their ability to polymerize …

Congenital hydrocephalus (CH), characterized by enlarged brain ventricles, is considered a
disease of excessive cerebrospinal fluid (CSF) accumulation and thereby treated with …

Formins are conserved actin polymerization machines that have instrumental roles in
controlling rearrangements of the actin cytoskeleton and have recently been shown to …

Cellular viability requires tight regulation of actin cytoskeletal dynamics. Distinct families of
nucleation-promoting factors enable the rapid assembly of filament nuclei that elongate and …

Recent observations related to the structure of the cytoskeleton in neurons and novel
cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases …

The small molecular inhibitor of formin FH2 domains, SMIFH2, is widely used in cell
biological studies. It inhibits formin-driven actin polymerization in vitro, but not …

Cell migration entails protrusion of lamellipodia, densely packed networks of actin filaments
at the cell front. Filaments are generated by nucleation, likely mediated by Arp2/3 complex …

A cell constantly adapts to its environment. Cell decisions to survive, to proliferate or to
migrate are dictated not only by soluble growth factors, but also through the direct interaction …

Rho GTPases are well known to regulate cell motility through activation of a variety of
downstream effector proteins, including enzymes, adaptor proteins and actin nucleators. The …