ABSTRACT World Health Organization has declared the ongoing outbreak of coronavirus
disease 2019 (COVID-19) a Public Health Emergency of International Concern. The virus …

The accessory protein Nef of human immunodeficiency virus (HIV) is a primary determinant
of viral pathogenesis. Nef is abundantly expressed during infection and reroutes a variety of …

The HIV-1 Nef protein suppresses multiple immune surveillance mechanisms to promote
viral pathogenesis and is an attractive target for the development of novel therapeutics. A …

Understanding of the range and mechanisms of clathrin functions has developed
exponentially since clathrin's discovery in 1975. Here, newly established molecular …

The evolutionary conflict between retroviruses and their vertebrate hosts over millions of
years has led to the emergence of cellular innate immune proteins termed restriction factors …

SERINC5 is a multipass intrinsic membrane protein that suppresses HIV-1 infectivity when
incorporated into budding virions. The HIV-1 Nef virulence factor prevents viral incorporation …

Human cells are equipped with a plethora of antiviral proteins protecting them against
invading viral pathogens. In contrast to apoptotic or pyroptotic cell death, which serves as …

Nef is an accessory protein unique to the primate HIV-1, HIV-2, and SIV lentiviruses. During
infection, Nef functions by interacting with multiple host proteins within infected cells to …

Methodological improvements in both single particle cryo-electron microscopy (cryo-EM)
and hydrogen/deuterium exchange mass spectrometry (HDX-MS) mean that the two …

ABSTRACT Serine incorporator 5 (SERINC5) reduces the infectivity of progeny HIV-1 virions
by incorporating into the outer host-derived viral membrane during egress. To counter …