Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …

Nicotinic receptors—a family of ligand-gated ion channels that mediate the effects of the
neurotransmitter acetylcholine—are among the most well understood allosteric membrane …

Herein we describe a novel series of compounds from which varenicline (1, 6, 7, 8, 9-
tetrahydro-6, 10-methano-6 H-pyrazino [2, 3-h][3] benzazepine) has been identified for …

The preclinical pharmacology of the α4β2 nicotinic acetylcholine receptor (nAChR) partial
agonist varenicline, a novel smoking cessation agent is described. Varenicline binds with …

The neurotransmitter acetylcholine (ACh) exerts its effects on the central nervous system
(CNS) and peripheral nervous system (PNS) through two distinct types of receptors: the …

Although long-acting bronchodilators have been an important advance for the management
of chronic obstructive pulmonary disease (COPD), these drugs do not deal with the …

α6* nicotinic acetylcholine receptors (nAChRs) are highly and selectively expressed by
mesostriatal dopamine (DA) neurons. These neurons are thought to mediate several …

Most smokers repeatedly fail in their attempts to stop smoking because of the addictive
nature of the nicotine in tobacco products. Nicotine dependence is probably mediated …

Addictive drugs can activate systems involved in normal reward-related learning, creating
long-lasting memories of the drug's reinforcing effects and the environmental cues …

Background and purpose: Smoking cessation trials with three high‐affinity partial agonists of
α4β2 neuronal nicotinic acetylcholine receptors (nAChRs) have demonstrated differences in …