Neurobiological mechanisms of nicotine reward and aversion
Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …
Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system
A Taly, PJ Corringer, D Guedin, P Lestage… - Nature reviews Drug …, 2009 - nature.com
Nicotinic receptors—a family of ligand-gated ion channels that mediate the effects of the
neurotransmitter acetylcholine—are among the most well understood allosteric membrane …
neurotransmitter acetylcholine—are among the most well understood allosteric membrane …
Varenicline: an α4β2 nicotinic receptor partial agonist for smoking cessation
JW Coe, PR Brooks, MG Vetelino… - Journal of medicinal …, 2005 - ACS Publications
Herein we describe a novel series of compounds from which varenicline (1, 6, 7, 8, 9-
tetrahydro-6, 10-methano-6 H-pyrazino [2, 3-h][3] benzazepine) has been identified for …
tetrahydro-6, 10-methano-6 H-pyrazino [2, 3-h][3] benzazepine) has been identified for …
Pharmacological profile of the α4β2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid
H Rollema, LK Chambers, JW Coe, J Glowa… - …, 2007 - Elsevier
The preclinical pharmacology of the α4β2 nicotinic acetylcholine receptor (nAChR) partial
agonist varenicline, a novel smoking cessation agent is described. Varenicline binds with …
agonist varenicline, a novel smoking cessation agent is described. Varenicline binds with …
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations
AA Jensen, B Frølund, T Liljefors… - Journal of medicinal …, 2005 - ACS Publications
The neurotransmitter acetylcholine (ACh) exerts its effects on the central nervous system
(CNS) and peripheral nervous system (PNS) through two distinct types of receptors: the …
(CNS) and peripheral nervous system (PNS) through two distinct types of receptors: the …
COPD: current therapeutic interventions and future approaches
PJ Barnes, RA Stockley - European Respiratory Journal, 2005 - Eur Respiratory Soc
Although long-acting bronchodilators have been an important advance for the management
of chronic obstructive pulmonary disease (COPD), these drugs do not deal with the …
of chronic obstructive pulmonary disease (COPD), these drugs do not deal with the …
Nicotinic acetylcholine receptors in the mesolimbic pathway: primary role of ventral tegmental area α6β2* receptors in mediating systemic nicotine effects on …
C Gotti, S Guiducci, V Tedesco, S Corbioli… - Journal of …, 2010 - Soc Neuroscience
α6* nicotinic acetylcholine receptors (nAChRs) are highly and selectively expressed by
mesostriatal dopamine (DA) neurons. These neurons are thought to mediate several …
mesostriatal dopamine (DA) neurons. These neurons are thought to mediate several …
Rationale, pharmacology and clinical efficacy of partial agonists of α4β2 nACh receptors for smoking cessation
H Rollema, JW Coe, LK Chambers, RS Hurst… - Trends in …, 2007 - cell.com
Most smokers repeatedly fail in their attempts to stop smoking because of the addictive
nature of the nicotine in tobacco products. Nicotine dependence is probably mediated …
nature of the nicotine in tobacco products. Nicotine dependence is probably mediated …
Neuronal nicotinic acetylcholine receptors: neuroplastic changes underlying alcohol and nicotine addictions
AA Feduccia, S Chatterjee, SE Bartlett - Frontiers in molecular …, 2012 - frontiersin.org
Addictive drugs can activate systems involved in normal reward-related learning, creating
long-lasting memories of the drug's reinforcing effects and the environmental cues …
long-lasting memories of the drug's reinforcing effects and the environmental cues …
Pre‐clinical properties of the α4β2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine …
H Rollema, A Shrikhande, KM Ward… - British journal of …, 2010 - Wiley Online Library
Background and purpose: Smoking cessation trials with three high‐affinity partial agonists of
α4β2 neuronal nicotinic acetylcholine receptors (nAChRs) have demonstrated differences in …
α4β2 neuronal nicotinic acetylcholine receptors (nAChRs) have demonstrated differences in …