Freeze-drying of nanoparticles: How to overcome colloidal instability by formulation and process optimization

E Trenkenschuh, W Friess - European journal of pharmaceutics and …, 2021 - Elsevier
Lyophilization of nanoparticle (NP) suspensions is a promising technology to improve
stability, especially during long-term storage, and offers new routes of administration in solid …

Nanoencapsulation techniques for food bioactive components: a review

PN Ezhilarasi, P Karthik, N Chhanwal… - Food and bioprocess …, 2013 - Springer
The protection and controlled release of bioactive compounds at the right time and the right
place can be implemented by encapsulation. Nanoencapsulation remains to be the one of …

Polymer-based nanocapsules for drug delivery

CE Mora-Huertas, H Fessi, A Elaissari - International journal of …, 2010 - Elsevier
A review of the state of knowledge on nanocapsules prepared from preformed polymers as
active substances carriers is presented. This entails a general review of the different …

To protect and to preserve: novel preservation strategies for extracellular vesicles

GD Kusuma, M Barabadi, JL Tan… - Frontiers in …, 2018 - frontiersin.org
Extracellular vesicles (EVs)-based therapeutics are based on the premise that EVs shed by
stem cells exert similar therapeutic effects and these have been proposed as an alternative …

Freeze-drying of nanoparticles: formulation, process and storage considerations

W Abdelwahed, G Degobert, S Stainmesse… - Advanced drug delivery …, 2006 - Elsevier
Freeze-drying has been considered as a good technique to improve the long-term stability of
colloidal nanoparticles. The poor stability in an aqueous medium of these systems forms a …

Methods for the preparation and manufacture of polymeric nanoparticles

C Vauthier, K Bouchemal - Pharmaceutical research, 2009 - Springer
This review summarizes the different methods of preparation of polymer nanoparticles
including nanospheres and nanocapsules. The first part summarizes the basic principle of …

Facts and evidences on the lyophilization of polymeric nanoparticles for drug delivery

P Fonte, S Reis, B Sarmento - Journal of controlled release, 2016 - Elsevier
Lyophilization has been used to improve the long-term stability of polymeric nanoparticles
for drug delivery applications, avoiding their instability in suspension. However, this …

Controlling drug nanoparticle formation by rapid precipitation

SM D'Addio, RK Prud'homme - Advanced drug delivery reviews, 2011 - Elsevier
Nanoparticles are a drug delivery platform that can enhance the efficacy of active
pharmaceutical ingredients, including poorly-water soluble compounds, ionic drugs …

Silk nanospheres and microspheres from silk/pva blend films for drug delivery

X Wang, T Yucel, Q Lu, X Hu, DL Kaplan - Biomaterials, 2010 - Elsevier
Silk fibroin protein-based micro-and nanospheres provide new options for drug delivery due
to their biocompatibility, biodegradability and their tunable drug loading and release …

Influence of process and formulation parameters on the formation of submicron particles by solvent displacement and emulsification–diffusion methods: Critical …

CE Mora-Huertas, H Fessi, A Elaissari - Advances in colloid and interface …, 2011 - Elsevier
Solvent displacement and emulsification–diffusion are the methods used most often for
preparing biodegradable submicron particles. The major difference between them is the …