Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets
EW Tate, L Soday, AL de la Lastra, M Wang… - Nature Reviews …, 2024 - nature.com
Protein lipidation describes a diverse class of post-translational modifications (PTMs) that is
regulated by over 40 enzymes, targeting more than 1,000 substrates at over 3,000 sites …
regulated by over 40 enzymes, targeting more than 1,000 substrates at over 3,000 sites …
Zebrafish models for studying cognitive enhancers
Cognitive decline is commonly seen both in normal aging and in neurodegenerative and
neuropsychiatric diseases. Various experimental animal models represent a valuable tool to …
neuropsychiatric diseases. Various experimental animal models represent a valuable tool to …
Biallelic pathogenic variants in TRMT1 disrupt tRNA modification and induce a syndromic neurodevelopmental disorder
S Efthymiou, C Leo, C Deng, K Zhang, SJ Lin… - medRxiv, 2024 - medrxiv.org
The post-transcriptional modification of tRNAs plays a key role in tRNA folding and function
to ensure proper levels of protein synthesis during growth and development. Pathogenic …
to ensure proper levels of protein synthesis during growth and development. Pathogenic …
[PDF][PDF] Deliverable
Solve-RD aims to find a diagnosis for rare disease patients who did not get a molecular
diagnosis yet. In addition to research re-analysis of existing exome and genome data, we …
diagnosis yet. In addition to research re-analysis of existing exome and genome data, we …