▪ Abstract The energy landscape theory of protein folding is a statistical description of a
protein's potential surface. It assumes that folding occurs through organizing an ensemble of …

From Levinthalto pathways to funnels Page 1 TS 9 1997 Nature Publishing Group http://www.nature.com/nsmb
perspective From Levinthalto pathways to funnels Ken A. Dill and Hue Sun Chan A new …

The recent availability of long equilibrium simulations of protein folding in atomistic detail for
more than 10 proteins allows us to identify the key interactions driving folding. We find that …

The understanding, and even the description of protein folding is impeded by the complexity
of the process. Much of this complexity can be described and understood by taking a …

The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …

A lattice model of protein folding is developed to distinguish between amino acid sequences
that do and do not fold into unique conformations. Although Monte Carlo simulations provide …

General principles of protein structure, stability, and folding kinetics have recently been
explored in computer simulations of simple exact lattice models. These models represent …

Publisher Summary This chapter describes the present state of the studies of the molten
globule state and its role in protein folding and physiological processes. Recent data on the …

We present a method to predict complex structural (conformational) transitions in irregular or
disordered macromolecular systems, such as proteins or glasses, at the atomic level. Our …

THE number of all possible conformations of a polypeptide chain is too large to be sampled
exhaustively. Nevertheless, protein sequences do fold into unique native states in seconds …