In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Endocannabinoids (eCBs) are amongst the most ubiquitous signaling molecules in the
nervous system. Over the past few decades, observations based on a large volume of work …

The AMPA receptor (AMPAR) GluR2 subunit dictates the critical biophysical properties of the
receptor, strongly influences receptor assembly and trafficking, and plays pivotal roles in a …

The CA3 region of the hippocampus is important for rapid encoding of memory.
Computational theories have proposed specific roles in hippocampal function and memory …

The dentate gyrus provides the main input to the hippocampus. Information reaches the CA3
region through mossy fibre synapses made by dentate granule cell axons. Synaptic plasticity …

Homeostatic synaptic scaling alters the strength of synapses to compensate for prolonged
changes in network activity and involves both excitatory and inhibitory neurons. The …

Although vastly outnumbered, inhibitory interneurons critically pace and synchronize
excitatory principal cell populations to coordinate cortical information processing. Precision …

Glutamate acts on postsynaptic glutamate receptors to mediate excitatory communication
between neurons. The discovery that additional presynaptic glutamate receptors can …

The precise patterns of neuronal assembly during development determine all functional
outputs of a nervous system; these may range from simple reflexes to learning, memory …

Until recently, the study of plasticity of neural circuits focused almost exclusively on
potentiation and depression at excitatory synapses on principal cells. Other elements in the …