Rodent models for metabolic syndrome research

SK Panchal, L Brown - BioMed Research International, 2011 - Wiley Online Library
Rodents are widely used to mimic human diseases to improve understanding of the causes
and progression of disease symptoms and to test potential therapeutic interventions …

Streptozotocin‐induced diabetes models: Pathophysiological mechanisms and fetal outcomes

DC Damasceno, AO Netto, IL Iessi… - BioMed research …, 2014 - Wiley Online Library
Glucose homeostasis is controlled by endocrine pancreatic cells, and any pancreatic
disturbance can result in diabetes. Because 8% to 12% of diabetic pregnant women present …

Effects of dietary zinc oxide nanoparticles on growth performance and antioxidative status in broilers

CY Zhao, SX Tan, XY Xiao, XS Qiu, JQ Pan… - Biological trace element …, 2014 - Springer
Broilers in four groups were fed a basal diet supplemented with 60 mg/kg zinc oxide (60-
ZnO; control), or 20, 60, or 100 mg/kg ZnO nanoparticles (20-, 60-, and 100-nano-ZnO …

High‐energy diets may induce a pre‐diabetic state altering testicular glycolytic metabolic profile and male reproductive parameters

L Rato, MG Alves, TR Dias, G Lopes, JE Cavaco… - …, 2013 - Wiley Online Library
Diabetes mellitus is a metabolic disorder that may arise from diet habits and is growing to
epidemic proportions. Young male diabetic patients present high infertility/subfertility …

[HTML][HTML] Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress

L Rato, AI Duarte, GD Tomas, MS Santos… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Pre-diabetes, a risk factor for type 2 diabetes development, leads to metabolic changes at
testicular level. Peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1α) and …

Impact of dietary nano-zinc oxide on immune response and antioxidant defense of broiler chickens

A Hafez, E Nassef, M Fahmy, M Elsabagh… - … Science and Pollution …, 2020 - Springer
This study aimed to elucidate the response of broiler chickens to the dietary nano-zinc
supplementation in terms of immune response and antioxidant activity. Ninety-one-day-old …

Protective effects of zinc oxide nanoparticles against doxorubicin induced testicular toxicity and DNA damage in male rats

ZK El-Maddawy, WSH Abd El Naby - Toxicology research, 2019 - academic.oup.com
The present study aims to investigate the protective effects of zinc oxide nanoparticles (ZnO
NPs) on doxorubicin-induced testicular injury. Forty mature male rats were randomly …

Down-regulated miR-21 in gestational diabetes mellitus placenta induces PPAR-α to inhibit cell proliferation and infiltration

CY Guan, S Tian, JL Cao, XQ Wang… - … Syndrome and Obesity, 2020 - Taylor & Francis
Purpose This study aimed to investigate the role of miR-21 expression in the reduction of
placental function in GDM patients. Materials and Methods qRT-PCR was used to detect the …

Experimental diabetes impairs maternal reproductive performance in pregnant Wistar rats and their offspring

L Bequer, T Gómez, JL Molina, A Álvarez… - Systems biology in …, 2018 - Taylor & Francis
The aim of this study was to determine the effect of mild hyperglycemia on metabolism
during pregnancy, the maternal reproductive performance, and the characteristics of the …

Streptozotocin-induced diabetes mellitus in neonatal rats: an insight into its applications to induce diabetic complications

MA Baig, SS Panchal - Current diabetes reviews, 2020 - ingentaconnect.com
Background: Diabetic complications are the major contributor in the mortality of diabetic
patients despite controlling blood glucose level. In the journey of new drug discovery, animal …