Adeno-associated virus (AAV) vector-mediated gene delivery was recently approved for the
treatment of inherited blindness and spinal muscular atrophy, and long-term therapeutic …

Adeno-associated virus (AAV) vectors are the leading platform for gene delivery for the
treatment of a variety of human diseases. Recent advances in developing clinically …

Exercise training has been widely recognized as a healthy lifestyle as well as an effective
non-drug therapeutic strategy for cardiovascular diseases (CVD). Functional and …

The adeno-associated virus (AAV) is a small, nonpathogenic parvovirus, which depends on
helper factors to replicate. Those helper factors can be provided by coinfecting helper …

Virus-based cancer vaccines are nowadays considered an interesting approach in the field
of cancer immunotherapy, despite the observation that the majority of the immune responses …

Tissue inhibitor of metalloproteinase 3 (TIMP3) is unique among the four TIMPs due to its
extracellular matrix (ECM)-binding property and broad range of inhibitory substrates that …

Introduction Gene therapy is a promising approach to be applied in cardiac regeneration
after myocardial infarction and gene correction for inherited cardiomyopathies. However …

Nucleic acid-based therapy emerges as a powerful weapon for the treatment of tumors
thanks to its direct, effective, and lasting therapeutic effect. Encouragingly, continuous …

Gene therapy has been expected to become a novel treatment method since the structure of
DNA was discovered in 1953. The morbidity from cardiovascular diseases remains …

Heart failure represents the end point of a variety of cardiovascular diseases. It is a growing
health burden and a leading cause of death worldwide. To date, limited treatment options …