[HTML][HTML] The applied implications of epigenetics in anxiety, affective and stress-related disorders-A review and synthesis on psychosocial stress, psychotherapy and …

MA Schiele, MG Gottschalk, K Domschke - Clinical psychology review, 2020 - Elsevier
Mental disorders are highly complex and multifactorial in origin, comprising an elaborate
interplay of genetic and environmental factors. Epigenetic mechanisms such as DNA …

Systemic inflammation mediates age-related cognitive deficits

T Lin, GA Liu, E Perez, RD Rainer, M Febo… - Frontiers in Aging …, 2018 - frontiersin.org
The association between systemic inflammation and cognitive deficits is well-documented.
Further, previous studies have shown that systemic inflammation levels increase with age …

Pathophysiology and individualized treatment of hypothalamic obesity following craniopharyngioma and other suprasellar tumors: a systematic review

L van Iersel, KE Brokke, RAH Adan… - Endocrine …, 2019 - academic.oup.com
The development of hypothalamic obesity (HO) following craniopharyngioma (CP) and other
suprasellar tumors leads to reduced patient quality of life. No treatment algorithms are …

Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression

JS Danoff, KL Wroblewski, AJ Graves, GC Quinn… - Clinical …, 2021 - Springer
Background The neuropeptide oxytocin regulates mammalian social behavior. Disruptions
in oxytocin signaling are a feature of many psychopathologies. One commonly studied …

[HTML][HTML] Epigenetic variability in the human oxytocin receptor (OXTR) gene: A possible pathway from early life experiences to psychopathologies

EJ Kraaijenvanger, Y He, H Spencer, AK Smith… - Neuroscience & …, 2019 - Elsevier
The human oxytocin (OXT) system is implicated in the regulation of complex social
behaviors, as well as in psychopathologies characterized by social deficits. Emerging …

Decreased oxytocin plasma levels and oxytocin receptor expression associated with aggressive behavior in aggressive-impulsive disorders

M Diaz-Marsá, JM López-Villatoro… - Journal of Psychiatric …, 2024 - Elsevier
Introduction This study aims to enhance the understanding of the association between the
phenotypic and endophenotypic characteristics of impulsive-aggressive disorders, through …

Possible oxytocin-related biomarkers in anxiety and mood disorders

S Yoon, YK Kim - Progress in Neuro-Psychopharmacology and …, 2022 - Elsevier
Anxiety and mood disorders are prevalent, disabling, and frequently difficult to treat. Such
disorders are often comorbid and share similar characteristics. For more accurate diagnosis …

Abnormal neuronal morphology and altered synaptic proteins are restored by oxytocin in autism-related SHANK3 deficient model

A Reichova, Z Bacova, S Bukatova… - Molecular and Cellular …, 2020 - Elsevier
Oxytocin has been suggested as a potential therapeutic agent in autism and other
neuropsychiatric conditions. Although, the link between the deficit in “SH3 domain and …

Oxytocin receptor gene (OXTR) DNA methylation is associated with autism and related social traits–A systematic review

M Moerkerke, ML Bonte, N Daniels, V Chubar… - Research in Autism …, 2021 - Elsevier
There is emerging evidence implicating oxytocin receptor gene (OXTR) DNA methylation
(DNAm) in social behaviour. This review investigated its association with autism spectrum …

An epigenetic rheostat of experience: DNA methylation of OXTR as a mechanism of early life allostasis

JS Danoff, JJ Connelly, JP Morris… - Comprehensive …, 2021 - Elsevier
Oxytocin is a neuropeptide hormone which is involved in regulation of social behavior,
stress response, muscle contraction, and metabolism. Oxytocin signaling is dependent on its …