Genetic manipulation of porcine donors has significantly prolonged the survival of grafts
placed into nonhuman primate recipients, but anti-nonGal xenoantibodies and thrombosis …

Background Promising developments in porcine islet xenotransplantation could resolve the
donor pancreas shortage for patients with type 1 diabetes. Using α1, 3 …

Antibodies directed at non-gal xenoantigens are responsible for acute humoral xenograft
rejection when gal knockout (GalTKO) pig organs are transplanted into nonhuman primates …

Background Natural antibodies directed at carbohydrates reject porcine xenografts. They
are initially expressed in germline configuration and are encoded by a small number of …

Background: Recent work has indicated a role for anti‐Galα1‐3Gal (Gal) and anti‐non‐Gal
xenoantibodies in the primate humoral rejection response against human‐decay …

Synthetic anti‐idiotypic antibodies represent a potentially valuable tool for the isolation and
characterization of B cells that produce xenoantibodies. An anti‐idiotypic antibody that binds …

Glycome difference between human and non-human species is the most basic concept as a
main barrier of xenotransplantation. Determination of xenogeneic carbohydrate antigens …

Background Xenotransplantation of porcine organs holds promise of solving the human
organ donor shortage. The use of α‐1, 3‐galactosyltransferase knockout (GTKO) pig donors …

Background Survival of vascularized xenografts is dependent on pre‐emptive inhibition of
the xenoantibody response against galactosyltransferase knockout (GTKO) porcine organs …

The article presents three studies related to xenotransplantation conducted from September
to October 2006. One study reviews liver support strategies, such as blood purification …