Respiratory function has become a global health priority. Not only is chronic respiratory
disease a leading cause of worldwide morbidity and mortality, but the COVID-19 pandemic …

In health, the near-eucapnic, highly efficient hyperpnea during mild-to-moderate intensity
exercise is driven by three obligatory contributions, namely, feedforward central command …

In patients with chronic obstructive pulmonary disease (COPD), exertional dyspnoea
generally arises when there is imbalance between ventilatory demand and capacity, but the …

Increased ventilation relative to metabolic demands, indicating alveolar hyperventilation
and/or increased physiological dead space (excess ventilation), is a key cause of exertional …

Cardiopulmonary exercise testing (CPET) remains poorly understood and, consequently,
largely underused in respiratory medicine. In addition to a widespread lack of knowledge of …

Low resting inspiratory capacity (IC) and low maximal inspiratory pressure (MIP) have
previously been linked to exertional dyspnea, exercise limitation, and poor survival in …

The functional disturbances driving “out-of-proportion” dyspnoea in patients with fibrosing
interstitial lung disease (f-ILD) showing only mild restrictive abnormalities remain poorly …

It is a challenge to keep abreast of all the clinical and scientific advances in the field of
respiratory medicine. This article contains an overview of laboratory-based science …

Rationale: It is increasingly recognized that adults with preserved ratio impaired spirometry
(PRISm) are prone to increased morbidity. However, the underlying pathophysiological …

Exertional dyspnea, a key complaint of patients with chronic obstructive pulmonary disease
(COPD), ultimately reflects an increased inspiratory neural drive to breathe. In non …