The brain requires a continuous supply of energy in the form of ATP, most of which is
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …

The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS)
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …

Axonal dysfunction is a common phenotype in neurodegenerative disorders, including in
amyotrophic lateral sclerosis (ALS), where the key pathological cell-type, the motor neuron …

Human studies consistently identify bioenergetic maladaptations in brains upon aging and
neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's …

Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease that is
classically thought to impact the motor system. Over the past 20 years, research has started …

Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disorder
primarily characterized by selective degeneration of both the upper motor neurons in the …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with no effective cure.
Astrocytes display a toxic phenotype in ALS and contribute to motoneuron (MN) …

Neuroinflammation is one of the main hallmarks of amyotrophic lateral sclerosis (ALS).
Recently, peripheral immune cells were discovered as pivotal players that promptly …

Astrocytes are the most abundant glial cell in the central nervous system and are involved in
multiple processes including metabolic homeostasis, blood brain barrier regulation and …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease
characterized by the progressive loss of motor neurons, for which current treatment options …