The Akt/protein kinase B is critical regulator of cellular homeostasis with diminished Akt
activity being associated with dysregulation of cellular metabolism and cell death while Akt …

We aimed to investigate mitochondrial function, biogenesis and autophagy in the brain of
type 2 diabetes (T2D) and Alzheimer's disease (AD) mice. Isolated brain mitochondria and …

High-fat diets are known to decrease muscle protein synthesis, the adaptation to overload,
and insulin sensitivity. Conditions that disrupt endoplasmic reticulum (ER) homeostasis lead …

The article discusses the effects of obesity on whole-body protein turnover. Several studies
revealed higher plasma concentrations of individual amino acids in obesity. A study found …

Obesity may impair protein synthesis rates and cause anabolic resistance to growth factors,
hormones, and exercise, ultimately affecting skeletal muscle mass and function. To better …

New Findings What is the central question of this study? Type 2 diabetes mellitus (T2DM)
causes skeletal muscle atrophy; does it affect resistance training (RT)‐mediated molecular …

Metabolic risk factors associated with insulin resistance syndrome may attenuate
augmentations in skeletal muscle protein anabolism following contractile activity. The …

Eccentric exercise results in prolonged muscle weakness and muscle soreness, which are
typical symptoms of muscle damage. Recovery from muscle damage is related to …

Aging and obesity contribute to insulin resistance with skeletal muscle being critically
important for maintaining whole-body glucose homeostasis. Both exercise and weight loss …

Recent data have suggested that insulin resistance may be associated with a diminished
ability of skeletal muscle to undergo hypertrophy (Paturi S, Gutta AK, Kakarla SK, Katta A …