In eukaryotes, poly (A) tails are present on almost every mRNA. Early experiments led to the
hypothesis that poly (A) tails and the cytoplasmic polyadenylate-binding protein (PABPC) …

Ribosome-associated quality-control (RQC) surveys incomplete nascent polypeptides
produced by interrupted translation. Central players in RQC are the human ribosome-and …

Ageing is accompanied by a decline in cellular proteostasis, which underlies many age-
related protein misfolding diseases,. Yet, how ageing impairs proteostasis remains unclear …

Abstract mRNA surveillance pathways are essential for accurate gene expression and to
maintain translation homeostasis, ensuring the production of fully functional proteins. Future …

Ribosomes catalyze protein synthesis by cycling through various functional states. These
states have been extensively characterized in vitro, but their distribution in actively …

The ribosome-associated protein quality control (RQC) system that resolves stalled
translation events is activated when ribosomes collide and form disome, trisome, or higher …

The Gcn pathway is conserved in all eukaryotes, including mammals such as humans,
where it is a crucial part of the integrated stress response (ISR). Gcn1 serves as an essential …

Ribosome rescue pathways recycle stalled ribosomes and target problematic mRNAs and
aborted proteins for degradation,. In bacteria, it remains unclear how rescue pathways …

Microbial pathogens deploy effector proteins to manipulate host cell innate immunity, often
using poorly understood unconventional secretion routes. Transfer RNA (tRNA) anticodon …

INTRODUCTION The tightly controlled process of gene expression requires messenger
RNAs (mRNAs), which represent DNA-derived blueprints for polypeptides, to be translated …