Increasing environmental distress is associated with a growing asthma incidence; no
treatments are available but montelukast (MTK)—an antagonist of the cysteinyl leukotrienes …

Prolonged or excessive stress may induce emotional and cognitive disturbances, and is a
risk factor for mental illnesses. Using rodent chronic stress models of depression, roles of …

Cysteinyl leukotrienes are a group of the inflammatory lipid molecules well known as
mediators of inflammatory signaling in the allergic diseases. Although they are traditionally …

Montelukast (MK), a cysteinyl leukotriene (CysLT1) receptor antagonist, latterly exhibited a
remarkable neuroprotective activity in various neurodegenerative disorders. This study aims …

Background Statins play a beneficial role in the treatment of coronary artery disease and are
widely prescribed to prevent hypercholesterolemia. Previous studies have demonstrated …

Eicosanoids are arachidonic acid (AA) derivatives belonging to a family of lipid signalling
mediators that are engaged in both physiological and pathological processes in the brain …

Depression is a chronic and progressive syndrome and commonly associated with several
neuropsychiatric comorbidities, of which depression is the most studied. It has been …

Despite the importance of lipid mediators in stress and depression and their link to
inflammation, the influence of stress on these mediators and their role in inflammation is not …

Severe and prolonged social stress induces mood and cognitive dysfunctions and
precipitates major depression. Neuroinflammation has been associated with chronic stress …

Our previous study suggests that hippocampal cysteinyl leukotriene receptor 1 (CysLT 1 R)
could be involved in depression. Herein we hypothesize that CysLT 1 R may regulate …