Single-cell multiomics: technologies and data analysis methods
Advances in single-cell isolation and barcoding technologies offer unprecedented
opportunities to profile DNA, mRNA, and proteins at a single-cell resolution. Recently, bulk …
opportunities to profile DNA, mRNA, and proteins at a single-cell resolution. Recently, bulk …
DNA methylation-based predictors of health: applications and statistical considerations
DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …
development, because, unlike static genetic risk estimates, DNA methylation varies …
Machine learning for integrating data in biology and medicine: Principles, practice, and opportunities
New technologies have enabled the investigation of biology and human health at an
unprecedented scale and in multiple dimensions. These dimensions include a myriad of …
unprecedented scale and in multiple dimensions. These dimensions include a myriad of …
[HTML][HTML] Integrated multi-omics analyses in oncology: a review of machine learning methods and tools
In recent years, high-throughput sequencing technologies provide unprecedented
opportunity to depict cancer samples at multiple molecular levels. The integration and …
opportunity to depict cancer samples at multiple molecular levels. The integration and …
Roles and mechanisms of BAP1 deubiquitinase in tumor suppression
The BAP1 gene has emerged as a major tumor suppressor mutated with various
frequencies in numerous human malignancies, including uveal melanoma, malignant …
frequencies in numerous human malignancies, including uveal melanoma, malignant …
Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer
M Arechederra, F Daian, A Yim, SK Bazai… - Nature …, 2018 - nature.com
Epigenetic modifications such as aberrant DNA methylation reshape the gene expression
repertoire in cancer. Here, we used a clinically relevant hepatocellular carcinoma (HCC) …
repertoire in cancer. Here, we used a clinically relevant hepatocellular carcinoma (HCC) …
[PDF][PDF] Probing the tumor suppressor function of BAP1 in CRISPR-engineered human liver organoids
The deubiquitinating enzyme BAP1 is a tumor suppressor, among others involved in
cholangiocarcinoma. BAP1 has many proposed molecular targets, while its Drosophila …
cholangiocarcinoma. BAP1 has many proposed molecular targets, while its Drosophila …
Single-cell transcriptome profiling of the stepwise progression of head and neck cancer
JH Choi, BS Lee, JY Jang, YS Lee, HJ Kim… - Nature …, 2023 - nature.com
Head and neck squamous cell carcinoma (HNSCC) undergoes stepwise progression from
normal tissues to precancerous leukoplakia, primary HNSCC, and metastasized tumors. To …
normal tissues to precancerous leukoplakia, primary HNSCC, and metastasized tumors. To …
Prognostic cancer gene expression signatures: current status and challenges
Current staging systems of cancer are mainly based on the anatomical extent of disease.
They need refinement by biological parameters to improve stratification of patients for tumor …
They need refinement by biological parameters to improve stratification of patients for tumor …
Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism
Autism spectrum disorder (ASD) is a phenotypically and genetically heterogeneous
neurodevelopmental disorder. Despite this heterogeneity, previous studies have shown …
neurodevelopmental disorder. Despite this heterogeneity, previous studies have shown …