The transition from a fetus to a newborn is the most complex physiologic adaptation that
occurs in human experience. Before medicalization of delivery, the transition had to occur …

Thirty years ago, there was an emerging appreciation for the significance of oxidative stress
in newborn disease. This prompted a renewed interest in the impact of oxygen therapy for …

Persistent pulmonary hypertension of the newborn (PPHN) is a syndrome of failed
circulatory adaptation at birth, seen in about 2/1000 live born infants. While it is mostly seen …

Meconium aspiration syndrome is a clinical condition characterized by respiratory failure
occurring in neonates born through meconium-stained amniotic fluid. Worldwide, the …

In contrast to early lung development, a process exemplified by the branching of the
developing airways, the later development of the immature lung remains very poorly …

Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway.
On binding of NO to its prosthetic haem group, sGC catalyses the synthesis of the second …

Persistent pulmonary hypertension of the newborn (PPHN) is one of the main causes of
neonatal morbidity and mortality. It is characterized by sustained elevation of pulmonary …

Inhaled nitric oxide (iNO) is approved for use in persistent pulmonary hypertension of the
newborn (PPHN) but does not lead to sustained improvement in oxygenation in one-third of …

Congenital diaphragmatic hernia (CDH) is a complex syndrome that causes severe
hypoxemic respiratory failure and is associated with high mortality. CDH is characterized by …

The pulmonary circulation rapidly adapts at birth to establish lungs as the site of gas
exchange. Abnormal transition at birth and/or parenchymal lung disease can result in …