Hedgehog (Hh) signalling regulates hepatic fibrogenesis. MicroRNAs (miRNAs) mediate
various cellular processes; however, their role in liver fibrosis is unclear. Here we investigate …

Liver fibrosis is the common pathological change of chronic liver diseases characterized by
increased deposition of extracellular matrix and reduced matrix degradation. In response to …

Liver fibrosis accompanies the development of various chronic liver diseases and promotes
their progression. It is characterized by the abnormal accumulation of extracellular matrix …

In the present study, two prospective Salmonella delivery strains, JOL2782 and JOL2837,
were developed by gene deletions of lon and cpxR, which are related to cellular adhesion …

Hepatic fibrosis (HF) is a wound healing response featuring excessive deposition of the
extracellular matrix (ECM) and activation of hepatic stellate cells (HSCs) that occurs during …

Liver fibrosis is a major characteristic of liver disease. When the liver is damaged, quiescent
hepatic stellate cells (HSCs) transdifferentiate into proliferative myofibroblastic/activated …

The relationship between alcohol dehydrogenase (ADH) and liver fibrosis has been studied,
but the mechanism of ADH involvement in liver fibrosis remains unclear. The aim of the …

In order to foster animal welfare as well as high quality of research, many countries regulate
by law that the severity of animal experiments must be evaluated and considered when …

A universal vaccine is in high demand to address the uncertainties of antigenic drift and the
reduced effectiveness of current influenza vaccines. In this study, a strategy called …

Emerging evidence revealed that diabetes induces abnormal immune responses that result
in serious complications in organs. However, the effect of hyperglycemia on hepatic …