Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system
indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of …

The success of cancer immunotherapy relies on the knowledge of the tumor
microenvironment and the immune evasion mechanisms in which the tumor, stroma, and …

Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for
the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In …

The immune system plays a critical role in protecting hosts from the invasion of organisms.
CD4 T cells, as a key component of the immune system, are central in orchestrating adaptive …

T-regulatory cells (Tregs) represent a unique subpopulation of helper T-cells by maintaining
immune equilibrium using various mechanisms. The role of T-cell receptors (TCR) in …

Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …

Abstract Background and Aims Hypoxia is one of the central players in shaping the immune
context of the tumor microenvironment (TME). However, the complex interplay between …

Abstract N6-methyladenosine (m6A) modification plays important roles in various cellular
responses by regulating mRNA biology. However, how m6A modification is involved in …

The immune system is a tightly regulated network which allows the development of defense
mechanisms against foreign antigens and tolerance toward self-antigens. Regulatory T cells …

Crosstalk between neighboring cells underlies many biological processes, including cell
signaling, proliferation and differentiation. Current single-cell genomic technologies profile …