[HTML][HTML] Peptides as a platform for targeted therapeutics for cancer: Peptide–drug conjugates (PDCs)

BM Cooper, J Iegre, DH O'Donovan… - Chemical society …, 2021 - pubs.rsc.org
Peptides can offer the versatility needed for a successful oncology drug discovery approach.
Peptide–drug conjugates (PDCs) are an emerging targeted therapeutic that present …

Peptide–drug conjugates with different linkers for cancer therapy

M Alas, A Saghaeidehkordi, K Kaur - Journal of medicinal …, 2020 - ACS Publications
Drug conjugates are chemotherapeutic or cytotoxic agents covalently linked to targeting
ligands such as an antibody or a peptide via a linker. While antibody–drug conjugates …

Improvement of conventional anti-cancer drugs as new tools against multidrug resistant tumors

S Dallavalle, V Dobričić, L Lazzarato, E Gazzano… - Drug Resistance …, 2020 - Elsevier
Multidrug resistance (MDR) is the dominant cause of the failure of cancer chemotherapy.
The design of antitumor drugs that are able to evade MDR is rapidly evolving, showing that …

[HTML][HTML] Peptide-drug conjugates and their targets in advanced cancer therapies

P Hoppenz, S Els-Heindl, AG Beck-Sickinger - Frontiers in chemistry, 2020 - frontiersin.org
Cancer became recently the leading cause of death in industrialized countries. Even though
standard treatments achieve significant effects in growth inhibition and tumor elimination …

[HTML][HTML] Peptide–drug conjugates (PDCs): a novel trend of research and development on targeted therapy, hype or hope?

C Fu, L Yu, Y Miao, X Liu, Z Yu, M Wei - Acta Pharmaceutica Sinica B, 2023 - Elsevier
Peptide–drug conjugates (PDCs) are the next generation of targeted therapeutics drug after
antibody–drug conjugates (ADCs), with the core benefits of enhanced cellular permeability …

Brain penetrating peptides and peptide–drug conjugates to overcome the blood–brain barrier and target CNS diseases

X Zhou, QR Smith, X Liu - Wiley Interdisciplinary Reviews …, 2021 - Wiley Online Library
Nearly one in six people worldwide suffer from disorders of the central nervous system
(CNS). There is an urgent need for effective strategies to improve the success rates in CNS …

[HTML][HTML] Peptide-drug conjugates: a new hope for cancer management

VP Chavda, HK Solanki, M Davidson… - Molecules, 2022 - mdpi.com
Cancer remains the leading cause of death worldwide despite advances in treatment
options for patients. As such, safe and effective therapeutics are required. Short peptides …

[HTML][HTML] Biomolecule-mimetic nanomaterials for photothermal and photodynamic therapy of cancers: Bridging nanobiotechnology and biomedicine

P He, G Yang, D Zhu, H Kong… - Journal of …, 2022 - Springer
Nanomaterial-based phototherapy has become an important research direction for cancer
therapy, but it still to face some obstacles, such as the toxic side effects and low target …

[HTML][HTML] Novel peptide therapeutic approaches for cancer treatment

CM Li, P Haratipour, RG Lingeman, JJP Perry, L Gu… - Cells, 2021 - mdpi.com
Peptides are increasingly being developed for use as therapeutics to treat many ailments,
including cancer. Therapeutic peptides have the advantages of target specificity and low …

Self‐assembled peptide‐based nanodrugs: molecular design, synthesis, functionalization, and targeted tumor bioimaging and biotherapy

X Luan, H Kong, P He, G Yang, D Zhu, L Guo, G Wei - Small, 2023 - Wiley Online Library
Functional nanomaterials as nanodrugs based on the self‐assembly of inorganics,
polymers, and biomolecules have showed wide applications in biomedicine and tissue …