The shared role of amyloid-β (Aβ) deposition in cerebral amyloid angiopathy (CAA) and
Alzheimer disease (AD) is arguably the clearest instance of crosstalk between …

Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide.
Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and …

The Arctic mutation, encoding E693G in the amyloid precursor protein (APP) gene [E22G in
amyloid-β (Aβ)], causes dominantly inherited Alzheimer's disease. Here, we report the high …

Alzheimer's disease (AD) is characterized neuropathologically by neuronal cell loss,
extracellular neuritic plaques composed of β-amyloid (Aβ), and intracellular neurofibrillary …

Neurodegenerative diseases present a major and increasing burden in the societies
worldwide. With aging populations, the prevalence of neurodegenerative diseases is …

Mutations in both the amyloid precursor protein (APP) and the presenilin (PSEN) genes
cause familial Alzheimer's disease (FAD) with autosomal dominant inheritance and early …

One of the characteristic hallmarks of Alzheimer's disease (AD) is an accumulation of
amyloid β (Aβ) leading to plaque formation and toxic oligomeric Aβ complexes. Besides the …

Point mutations in the amyloid-β (Aβ) coding region produce a combination of mutant and
WT Aβ isoforms that yield unique clinicopathologies in familial Alzheimer's disease (fAD) …

Aberrant low γ-secretase activity is associated with most of the presenilin mutations that
underlie familial Alzheimer's disease (fAD). However, the role of γ-secretase in the more …

Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) peptide deposition in brain
parenchyma as plaques and in cerebral blood vessels as cerebral amyloid angiopathy …