Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human
pathogen that results in mucocutaneous lesions in the oral cavity or genital infections …

The concept of error threshold derived from quasispecies theory is at the basis of lethal
mutagenesis, a new antiviral strategy based on the increase of virus mutation rate above an …

Arboviruses cycle through both vertebrates and invertebrates, which requires them to adapt
to disparate hosts while maintaining genetic integrity during genome replication. To study …

Lethal mutagenesis is an antiviral approach that consists in extinguishing a virus by an
excess of mutations acquired during replication in the presence of a mutagen. Here we …

Lethal mutagenesis, or virus extinction produced by enhanced mutation rates, is under
investigation as an antiviral strategy that aims at counteracting the adaptive capacity of viral …

Apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3G (ie, APOBEC3G or
A3G) is an evolutionarily conserved cytosine deaminase that potently restricts human …

The concept of a mild mutagen was coined to describe a minor mutagenic activity exhibited
by some nucleoside analogues that potentiated their efficacy as antiretroviral agents. In the …

Despite having very limited coding capacity, RNA viruses are able to withstand challenge of
antiviral drugs, cause epidemics in previously exposed human populations, and, in some …

The notoriously low fidelity of HIV-1 replication is largely responsible for the virus's rapid
mutation rate, facilitating escape from immune or drug control. The error-prone activity of the …

Studies of retroviruses have led to many extraordinary discoveries that have advanced our
understanding of not only human diseases, but also molecular biology as a whole. The most …