Mitochondrial damage is implicated as a major contributing factor for a number of
noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and …

Alzheimer's disease (AD) is the most prevalent type of dementia. Down syndrome (DS) is the
leading genetic risk factor for Early-Onset AD, prematurely presenting the classic …

Rationale: Heart failure with preserved ejection fraction (HFpEF) is a mortal clinical
syndrome without effective therapies. We recently demonstrated in mice that a combination …

Heart failure with preserved ejection fraction (HFpEF) is now the dominant form of heart
failure and one for which no efficacious therapies exist. Obesity and lipid mishandling …

Fatty acid overload, either of the saturated palmitic acid (PA) or the unsaturated oleic acid
(OA), causes triglyceride accumulation into specialized organelles termed lipid droplets …

Background: BET (bromodomain and extraterminal) epigenetic reader proteins, in particular
BRD4 (bromodomain-containing protein 4), have emerged as potential therapeutic targets in …

Mesenchymal stem cells (MSCs) have therapeutic value in many diseases. Mitochondria
transfer can promote wound healing and can potentially be applied to the repair of damaged …

Myocardial infarction is one of the leading causes of death worldwide. Thus, protection
against myocardial ischemia-reperfusion injury is particularly important to improve the …

Mitochondrial dysfunctions have been described in Down syndrome (DS) caused by either
partial or full trisomy of chromosome 21 (HSA21). Mitochondria play a crucial role in various …

Abstract Angiotensin-(1–9) is a peptide from the noncanonical renin-angiotensin system with
anti-hypertrophic effects in cardiomyocytes via an unknown mechanism. In the present study …