Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Several epidemiological studies have clearly shown the high co-morbidity between
depression and Cardiovascular Diseases (CVD). Different studies have been conducted to …

Rationale Systemic inhibition of neuronal nitric oxide synthase (nNOS) induces
antidepressant-like effects in rodents. The mechanisms and brain regions mediating this …

Affective and anxiety disorders are widely distributed disorders with severe social and
economic effects. Evidence is emphatic that effective treatment helps to restore function and …

The effects of microinjection of the nitric oxide (NO) precursor l-arginine (l-Arg), the NO
synthase (NOS) inhibitors N-methyl-l-arginine (l-NAME) and 7-nitroindazole (7-NI), and the …

Recent findings demonstrated the dysregulation of imidazoline receptor binding sites in
major depression and their normalization by chronic treatment with antidepressants …

Taurine, a substrate of taurine transporter, has functions as a neuromodulator and
antioxidant and beta-alanine, a taurine transporter inhibitor, has a role as a neurotransmitter …

The effects of inhibitors of different subtypes of potassium (K+) channels were investigated in
the mouse forced swimming test (FST). The treatment of animals with tetraethylammonium …

Recent evidence has suggested that systemic administration of non-selective NOS inhibitors
induces antidepressant-like effects in animal models. However, the precise involvement of …

Millions of individuals worldwide suffers from mood disorders, especially major depressive
disorder (MDD), which has a high rate of disease burden in society. Although targeting the …