[HTML][HTML] New HBM values for emerging substances, inventory of reference and HBM values in force, and working principles of the German Human Biomonitoring …
P Apel, J Angerer, M Wilhelm… - International journal of …, 2017 - Elsevier
Abstract The German Human Biomonitoring Commission (HBM Commission) derives health-
related guidance values (Human Biomonitoring assessment values, HBM values) according …
related guidance values (Human Biomonitoring assessment values, HBM values) according …
[图书][B] Hayes' principles and methods of toxicology
AW Hayes, T Kobets - 2023 - taylorfrancis.com
Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …
informative reference for the concepts, methodologies, and assessments integral to …
Evaluation of physiologically based models of pregnancy and lactation for their application in children's health risk assessments
RA Corley, TJ Mast, EW Carney… - Critical reviews in …, 2003 - Taylor & Francis
In today's scientific and regulatory climates, an increased emphasis is placed on the
potential health impacts for children exposed either in utero or by nursing to drugs of abuse …
potential health impacts for children exposed either in utero or by nursing to drugs of abuse …
The Use of In Vitro Toxicity Data and Physiologically Based Kinetic Modeling to Predict Dose-Response Curves for In Vivo Developmental Toxicity of Glycol Ethers in …
J Louisse, E de Jong, JJM van de Sandt… - Toxicological …, 2010 - academic.oup.com
At present, regulatory assessment of systemic toxicity is almost solely carried out using
animal models. The European Commission's REACH legislation stimulates the use of …
animal models. The European Commission's REACH legislation stimulates the use of …
Advances in inhalation dosimetry models and methods for occupational risk assessment and exposure limit derivation
ED Kuempel, LM Sweeney, JB Morris… - … of occupational and …, 2015 - Taylor & Francis
The purpose of this article is to provide an overview and practical guide to occupational
health professionals concerning the derivation and use of dose estimates in risk assessment …
health professionals concerning the derivation and use of dose estimates in risk assessment …
Estimation of placental and lactational transfer and tissue distribution of atrazine and its main metabolites in rodent dams, fetuses, and neonates with physiologically …
Atrazine (ATR) is a widely used chlorotriazine herbicide, a ubiquitous environmental
contaminant, and a potential developmental toxicant. To quantitatively evaluate …
contaminant, and a potential developmental toxicant. To quantitatively evaluate …
Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling
M Verwei, JA van Burgsteden, CAM Krul… - Toxicology Letters, 2006 - Elsevier
The new EU legislations for chemicals (Registration, Evaluation and Authorization of
Chemicals, REACH) and cosmetics (Seventh Amendment) stimulate the acceptance of in …
Chemicals, REACH) and cosmetics (Seventh Amendment) stimulate the acceptance of in …
The mechanism of ethylene glycol ether reproductive and developmental toxicity and evidence for adverse effects in humans
F Welsch - Toxicology letters, 2005 - Elsevier
Numerous experimental studies have established that only a few among the large family of
ethylene glycol ethers (EGEs) elicit toxicity on reproduction in either gender. Notable are the …
ethylene glycol ethers (EGEs) elicit toxicity on reproduction in either gender. Notable are the …
The challenge of using read-across within the EU REACH regulatory framework; how much uncertainty is too much? Dipropylene glycol methyl ether acetate, an …
N Ball, M Bartels, R Budinsky, J Klapacz, S Hays… - Regulatory Toxicology …, 2014 - Elsevier
The use of read-across of data within a group of structurally similar substances potentially
allows one to characterise the hazards of a substance without resorting to additional animal …
allows one to characterise the hazards of a substance without resorting to additional animal …
Physiologically-based pharmacokinetic modeling for absorption, transport, metabolism and excretion
KS Pang, MR Durk - Journal of pharmacokinetics and pharmacodynamics, 2010 - Springer
The seminal paper on the liver physiologically-based pharmacokinetic (PBPK) model by
Rowland et al.(J Pharmacokinet Biopharm 1: 123–136, 1973) that described the influence of …
Rowland et al.(J Pharmacokinet Biopharm 1: 123–136, 1973) that described the influence of …