Systemic lupus erythematosus (SLE) is a clinically and genetically heterogeneous
autoimmune disease. The etiology of lupus and the contribution of genetic, environmental …

Most B cells produced in the bone marrow have some level of autoreactivity. Despite efforts
of central tolerance to eliminate these cells, many escape to periphery, where in healthy …

Growing evidence suggests that the tumor microenvironment (TME) plays crucial roles in
tumor progression and treatment efficacy in clear cell renal cell carcinoma (ccRCC), which …

Introduction The complex system of BAFF (B-cell-activating factor of the TNF family) and
APRIL (A proliferation-inducing ligand) has been studied in animal models of autoimmune …

Suppurative lung disease and wheezing are common respiratory diseases of childhood,
however, due to poor understanding of underlying pathobiology, there are limited treatment …

Accumulating evidence shows HOOK1 disordered in human malignancies. However, the
clinicopathological and biological significance of HOOK1 in renal cell carcinoma (RCC) …

Abstract BAFF, APRIL and BAFF-R are key proteins involved in the development of B-
lymphocytes and autoimmunity. Additionally, BAFF, APRIL and BAFFR polymorphisms were …

Rheumatoid arthritis (RA) has an estimated heritability of nearly 50%, which is particularly
high in seropositive RA. HLA alleles account for a large proportion of this heritability, in …

Systemic lupus erythematosus (SLE) is the prototype of an autoimmune disease.
Belimumab, a monoclonal antibody targets BAFF, is the only biologic approved for SLE and …

African swine fever, caused by African swine fever virus (ASFV), is a highly contagious and
fatal disease that poses a significant threat to the global pig industry. The limited information …