The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease

Y Döring, L Pawig, C Weber, H Noels - Frontiers in physiology, 2014 - frontiersin.org
The chemokine receptor CXCR4 and its ligand CXCL12 play an important homeostatic
function by mediating the homing of progenitor cells in the bone marrow and regulating their …

Homing of endogenous stem/progenitor cells for in situ tissue regeneration: promises, strategies, and translational perspectives

FM Chen, LA Wu, M Zhang, R Zhang, HH Sun - Biomaterials, 2011 - Elsevier
Stem cell-based therapy has been one of the best documented approaches in regenerative
medicine, promising cures for a multitude of diseases and disorders. However, the ex vivo …

[HTML][HTML] Bioengineering CXCR4-overexpressing cell membrane functionalized ROS-responsive nanotherapeutics for targeting cerebral ischemia-reperfusion injury

L Luo, G Zang, B Liu, X Qin, Y Zhang, Y Chen… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: As a potentially life-threatening disorder, cerebral ischemia-reperfusion (I/R)
injury is associated with significantly high mortality, especially the irreversible brain tissue …

Chemokines in CNS injury and repair

A Jaerve, HW Müller - Cell and tissue research, 2012 - Springer
Recruitment of inflammatory cells is known to drive the secondary damage cascades that
are common to injuries of the central nervous system (CNS). Cell activation and infiltration to …

Curcumin suppresses glioblastoma cell proliferation by p-AKT/mTOR pathway and increases the PTEN expression

Z Wang, F Liu, W Liao, L Yu, Z Hu, M Li, H Xia - Archives of Biochemistry …, 2020 - Elsevier
Background Glioblastoma (GB) is the most common neoplasm in the brain. Curcumin, as a
known polyphenolic compound extracted from turmeric, is a chemotherapy used in some …

CC and CXC chemokines are pivotal mediators of cerebral injury in ischaemic stroke

M Mirabelli-Badenier, V Braunersreuther… - Thrombosis and …, 2011 - thieme-connect.com
The definition of ischaemic stroke has been recently updated as an acute episode of
neurological dysfunction caused by focal brain, spinal cord, or retinal ischaemia in the …

The SDF-1/CXCR4 axis regulates migration of transplanted bone marrow mesenchymal stem cells towards the pancreas in rats with acute pancreatitis

J Gong, HB Meng, J Hua, ZS Song… - Molecular …, 2014 - spandidos-publications.com
Stromal cell-derived factor-1 (SDF-1) and its receptor, CXC chemokine receptor-4 (CXCR4),
are important regulators in the migration of bone marrow mesenchymal stem cells (BMSCs) …

Chemotactic recruitment of genetically engineered cell membrane-camouflaged metal− organic framework nanoparticles for ischemic osteonecrosis treatment

H Jiang, W Xia, T Xia, L Jiang, J Yu, X Zhu, C Lin… - Acta Biomaterialia, 2024 - Elsevier
Ischemic osteonecrosis, particularly glucocorticoid-induced osteonecrosis of the femoral
head (GIONFH), is primarily due to the dysfunction of osteogenesis and angiogenesis …

Migration of CXCR4 gene‐modified bone marrow‐derived mesenchymal stem cells to the acute injured kidney

N Liu, J Tian, J Cheng, J Zhang - Journal of cellular …, 2013 - Wiley Online Library
Bone marrow‐derived mesenchymal stem cells (BMSCs) can migrate to the injured kidney
after acute kidney injury (AKI) with limited efficiency. This study investigated the effect of …

Vasculoprotective effects of vildagliptin. Focus on atherogenesis

M Wiciński, K Górski, E Wódkiewicz, M Walczak… - International journal of …, 2020 - mdpi.com
Vildagliptin is a representative of Dipeptidyl Peptidase-4 (DPP-4) inhibitors,
antihyperglycemic drugs, approved for use as monotherapy and combination therapy in type …