Posttranslational modifications (PTMs) regulate protein functions and interactions. ADP-
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …

Many bacterial pathogens produce protein toxins to outmanoeuvre the immune system of
the host. Some of these proteins target regulatory GTPases such as those belonging to the …

Bacterial ADP-ribosyltransferase toxins (bARTTs) transfer ADP-ribose to eukaryotic proteins
to promote bacterial pathogenesis. In this Review, we use prototype bARTTs, such as …

Many bacterial cytotoxins act on eukaryotic cells by targeting the regulators that are involved
in controlling the cytoskeleton or by directly modifying actin, with members of the Rho …

Clostridia produce the highest number of toxins of any type of bacteria and are involved in
severe diseases in humans and other animals. Most of the clostridial toxins are pore-forming …

Ras-homologous (Rho) GTPases play a pivotal role in the regulation of numerous cellular
functions associated with malignant transformation and metastasis. Rho GTPases are …

Spinal cord injury (SCI) leads to robust Rho activation at the lesion site. Here, we
demonstrate that BA-210, a cell-permeable fusion protein derived from C3 transferase …

Small GTP‐binding proteins of the Rho/Rac/Cdc42 family combine their GDP/GTP cycle,
regulated by guanine nucleotide‐exchange factors and GTPase‐activating proteins, to a …

Clostridia is one of the largest bacterial genera with an enormous potential for biotechnical
and medical applications. Despite growing scientific, medical, and industrial interest …

Host cell invasion of the food‐borne pathogen Campylobacter jejuni is one of the primary
reasons of tissue damage in humans but molecular mechanisms are widely unclear. Here …