Regulation of adult neurogenesis in mammalian brain
Adult neurogenesis is a multistage process by which neurons are generated and integrated
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …
[HTML][HTML] Post-translational modification of SOX family proteins: Key biochemical targets in cancer?
Sox proteins are a family of lineage-associated transcription factors. They regulate
expression of genes involved in control of self-renewal and multipotency in both …
expression of genes involved in control of self-renewal and multipotency in both …
Central administration of afzelin extracted from Ribes fasciculatum improves cognitive and memory function in a mouse model of dementia
Neurodegenerative disorders are characterized by the decline of cognitive function and the
progressive loss of memory. The dysfunctions of the cognitive and memory system are …
progressive loss of memory. The dysfunctions of the cognitive and memory system are …
Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex
F Da Silva, K Zhang, A Pinson, E Fatti… - The EMBO …, 2021 - embopress.org
The role of WNT/β‐catenin signalling in mouse neocortex development remains ambiguous.
Most studies demonstrate that WNT/β‐catenin regulates progenitor self‐renewal but others …
Most studies demonstrate that WNT/β‐catenin regulates progenitor self‐renewal but others …
Role of the CDKL1-SOX11 signaling axis in acute kidney injury
JA Silvaroli, GV Martinez… - American Journal …, 2024 - journals.physiology.org
The biology of the cyclin-dependent kinase-like (CDKL) kinase family remains enigmatic.
Contrary to their nomenclature, CDKLs do not rely on cyclins for activation and are not …
Contrary to their nomenclature, CDKLs do not rely on cyclins for activation and are not …
cFOS as a biomarker of activity maturation in the hippocampal formation
M Pompeiano, MT Colonnese - Frontiers in neuroscience, 2023 - frontiersin.org
We explored the potential for cFOS expression as a marker of functional development of
“resting-state” waking activity in the extended network of the hippocampus and entorhinal …
“resting-state” waking activity in the extended network of the hippocampus and entorhinal …
Phosphorylation of Serine 114 of the transcription factor ABSCISIC ACID INSENSITIVE 4 is essential for activity
The transcription factor ABA-INSENSITIVE (ABI) 4 has diverse roles in regulating plant
growth, including inhibiting germination and reserve mobilization in response to ABA and …
growth, including inhibiting germination and reserve mobilization in response to ABA and …
scRNA sequencing uncovers a TCF4-dependent transcription factor network regulating commissure development in mouse
MT Wittmann, S Katada, E Sock, P Kirchner… - …, 2021 - journals.biologists.com
ABSTRACT Transcription factor 4 (TCF4) is a crucial regulator of neurodevelopment and
has been linked to the pathogenesis of autism, intellectual disability and schizophrenia. As a …
has been linked to the pathogenesis of autism, intellectual disability and schizophrenia. As a …
[HTML][HTML] 性别决定区Y 相关高迁移率族盒蛋白11 在中枢神经系统分化, 发育与再生中的作用
侯晓翔， 王春晖， 王君玉， 张丹枫 - 海军军医大学学报, 2024 - html.rhhz.net
性别决定区Y 相关高迁移率族盒蛋白11 (SOX11) 最初被认为是支持干细胞神经元分化和神经前
体细胞存活的反式作用因子之一. 但深入研究发现, SOX11 在神经元发育, 重塑及再生中都具有 …
体细胞存活的反式作用因子之一. 但深入研究发现, SOX11 在神经元发育, 重塑及再生中都具有 …
Ufd1 phosphorylation at serine 229 negatively regulates endoplasmic reticulum-associated degradation by inhibiting the interaction of Ufd1 with VCP
QAT Nguyen, J Choi, JK Yang, SY Lee - Biochemical Journal, 2019 - portlandpress.com
Misfolded proteins in the endoplasmic reticulum (ER) are removed through multistep
processes termed ER-associated degradation (ERAD). Valosin-containing protein (VCP) …
processes termed ER-associated degradation (ERAD). Valosin-containing protein (VCP) …