Endothelial dysfunction is a major contributing factor to diseases such as atherosclerosis,
diabetes mellitus, obesity, hypertension, acute lung injury, preeclampsia, among others …

Sirtuins are a family of NAD+-dependent deacylases with numerous physiological and
pathological implications, which lately became an attractive therapeutic target. Sirtuin …

Excessive bone erosion by osteoclasts is associated with osteoporosis, rheumatoid arthritis,
and periprosthetic osteolysis. Targeting osteoclasts may serve as an effective treatment for …

Cancer therapy through anticancer drugs and radiotherapy is associated with several side
effects as well as tumor resistance to therapy. The genotoxic effects of chemotherapy and …

Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …

Biological targeting or molecular targeting is the main strategy in drug development and
disease prevention. However, the problem of “off-targets” cannot be neglected. Naturally …

Natural stilbenes have unique physiological effects, such as anti-senile dementia, anti-
cancer, anti-bacterial, lowering blood lipid, and other important biological functions, which …

Aging is an unavoidable part of life. The more aged we become, the more susceptible we
become to various complications and damages to the vital organs, including the kidneys …

Vascular smooth muscle cells (SMCs) are circumferentially oriented perpendicular to the
blood vessel and maintain the contractile phenotype in physiological conditions. They can …

Pulmonary hypertension (PH) is a progressive, pulmonary vascular disease with high
morbidity and mortality. Unfortunately, the pathogenesis of PH is complex and remains …