Stepping forward in antibody-drug conjugate development

Y Jin, MA Schladetsch, X Huang, MJ Balunas… - Pharmacology & …, 2022 - Elsevier
Antibody-drug conjugates (ADCs) are cancer therapeutic agents comprised of an antibody,
a linker and a small-molecule payload. ADCs use the specificity of the antibody to target the …

Exploration of the antibody–drug conjugate clinical landscape

H Maecker, V Jonnalagadda, S Bhakta… - MAbs, 2023 - Taylor & Francis
The antibody–drug conjugate (ADC) field has undergone a renaissance, with substantial
recent developmental investment and subsequent drug approvals over the past 6 years. In …

Multiple myeloma therapy: emerging trends and challenges

D Dima, D Jiang, DJ Singh, M Hasipek, HS Shah… - Cancers, 2022 - mdpi.com
Simple Summary Multiple myeloma (MM) is a frequent hematological malignancy
characterized by the uncontrolled growth of clonal plasma cells, primarily in the bone …

BCMA loss in the epoch of novel immunotherapy for multiple myeloma: from biology to clinical practice

X Zhou, L Rasche, KM Kortüm, J Mersi… - …, 2022 - pmc.ncbi.nlm.nih.gov
The treatment of multiple myeloma (MM) is evolving rapidly. In the past few years, chimeric
antigen receptor modified T cells and bispecific antibodies are bringing new treatment …

Relapsed/refractory multiple myeloma in 2020/2021 and beyond

K Podar, X Leleu - Cancers, 2021 - mdpi.com
Simple Summary During the last two decades, collaborative translational studies utilizing
novel methodologies have dramatically advanced our understanding of multiple myeloma …

Antibodies and bispecifics for multiple myeloma: effective effector therapy

C Cipkar, C Chen, S Trudel - Hematology, 2022 - ashpublications.org
The therapeutic landscape in multiple myeloma (MM) has changed dramatically over the last
2 decades. With the introduction of novel immunotherapies, patients with MM can expect …

BCMA in multiple myeloma—a promising key to therapy

M Kleber, I Ntanasis-Stathopoulos… - Journal of clinical medicine, 2021 - mdpi.com
Despite the discoveries of numerous agents including next generation proteasome
inhibitors, immunomodulatory drugs, and monoclonal antibodies, multiple myeloma (MM) …

Chimeric antigen receptor T‐cells, bispecific antibodies, and antibody‐drug conjugates for multiple myeloma: an update

A Lakshman, SK Kumar - American journal of hematology, 2022 - Wiley Online Library
Patients with multiple myeloma who are refractory to currently available effective therapies
have short expected survival. Modalities harvesting the knowledge of the immune …

Targeted immunotherapy: harnessing the immune system to battle multiple myeloma

L Xu, C Wen, J Xia, H Zhang, Y Liang, X Xu - Cell Death Discovery, 2024 - nature.com
Multiple myeloma (MM) remains an incurable hematological malignancy disease
characterized by the progressive dysfunction of the patient's immune system. In this context …

Immunotherapy of multiple myeloma: current status as prologue to the future

HN Abramson - International Journal of Molecular Sciences, 2023 - mdpi.com
The landscape of therapeutic measures to treat multiple myeloma has undergone a seismic
shift since the dawn of the current century. This has been driven largely by the introduction of …