Stepping forward in antibody-drug conjugate development
Antibody-drug conjugates (ADCs) are cancer therapeutic agents comprised of an antibody,
a linker and a small-molecule payload. ADCs use the specificity of the antibody to target the …
a linker and a small-molecule payload. ADCs use the specificity of the antibody to target the …
Exploration of the antibody–drug conjugate clinical landscape
H Maecker, V Jonnalagadda, S Bhakta… - MAbs, 2023 - Taylor & Francis
The antibody–drug conjugate (ADC) field has undergone a renaissance, with substantial
recent developmental investment and subsequent drug approvals over the past 6 years. In …
recent developmental investment and subsequent drug approvals over the past 6 years. In …
Multiple myeloma therapy: emerging trends and challenges
Simple Summary Multiple myeloma (MM) is a frequent hematological malignancy
characterized by the uncontrolled growth of clonal plasma cells, primarily in the bone …
characterized by the uncontrolled growth of clonal plasma cells, primarily in the bone …
BCMA loss in the epoch of novel immunotherapy for multiple myeloma: from biology to clinical practice
The treatment of multiple myeloma (MM) is evolving rapidly. In the past few years, chimeric
antigen receptor modified T cells and bispecific antibodies are bringing new treatment …
antigen receptor modified T cells and bispecific antibodies are bringing new treatment …
Relapsed/refractory multiple myeloma in 2020/2021 and beyond
K Podar, X Leleu - Cancers, 2021 - mdpi.com
Simple Summary During the last two decades, collaborative translational studies utilizing
novel methodologies have dramatically advanced our understanding of multiple myeloma …
novel methodologies have dramatically advanced our understanding of multiple myeloma …
Antibodies and bispecifics for multiple myeloma: effective effector therapy
C Cipkar, C Chen, S Trudel - Hematology, 2022 - ashpublications.org
The therapeutic landscape in multiple myeloma (MM) has changed dramatically over the last
2 decades. With the introduction of novel immunotherapies, patients with MM can expect …
2 decades. With the introduction of novel immunotherapies, patients with MM can expect …
BCMA in multiple myeloma—a promising key to therapy
M Kleber, I Ntanasis-Stathopoulos… - Journal of clinical medicine, 2021 - mdpi.com
Despite the discoveries of numerous agents including next generation proteasome
inhibitors, immunomodulatory drugs, and monoclonal antibodies, multiple myeloma (MM) …
inhibitors, immunomodulatory drugs, and monoclonal antibodies, multiple myeloma (MM) …
Chimeric antigen receptor T‐cells, bispecific antibodies, and antibody‐drug conjugates for multiple myeloma: an update
A Lakshman, SK Kumar - American journal of hematology, 2022 - Wiley Online Library
Patients with multiple myeloma who are refractory to currently available effective therapies
have short expected survival. Modalities harvesting the knowledge of the immune …
have short expected survival. Modalities harvesting the knowledge of the immune …
Targeted immunotherapy: harnessing the immune system to battle multiple myeloma
L Xu, C Wen, J Xia, H Zhang, Y Liang, X Xu - Cell Death Discovery, 2024 - nature.com
Multiple myeloma (MM) remains an incurable hematological malignancy disease
characterized by the progressive dysfunction of the patient's immune system. In this context …
characterized by the progressive dysfunction of the patient's immune system. In this context …
Immunotherapy of multiple myeloma: current status as prologue to the future
HN Abramson - International Journal of Molecular Sciences, 2023 - mdpi.com
The landscape of therapeutic measures to treat multiple myeloma has undergone a seismic
shift since the dawn of the current century. This has been driven largely by the introduction of …
shift since the dawn of the current century. This has been driven largely by the introduction of …