The late‐stage modification of structurally complex peptides bears great potential for drug
discovery, crop protection, and the pharmaceutical industry, among others. Whereas …

Recently developed strategies for late stage modification of peptides through Csingle bondH
activation, an arena of contemporary interest in chemical biology and drug discovery, are …

Late‐stage BODIPY diversification of structurally complex amino acids and peptides was
accomplished by racemization‐free palladium‐catalyzed C (sp3)− H activation …

Late-stage diversification of structurally complex amino acids and peptides provides
tremendous potential for drug discovery and molecular imaging. Specifically, labeling …

Late-stage modification of peptides and proteins meets the increasing demand in
biochemical and pharmaceutical communities. These modification strategies could provide …

Herein, an efficient and regioselective Rh (III)‐catalyzed [4+ 2] annulation/lactonization
cascade of indoles with 4‐hydroxy‐2‐alkynoates at room temperature to access the furo …

The functionalization of typically unreactive C (sp 3)–H bonds holds great promise for
reducing the reliance on existing functional groups while improving atom-economy and …

Ru (II)-catalyzed redox-neutral [3+ 2] annulation reactions of N-ethoxycarbamoyl indoles
and internal alkynes via C–H bond activation are reported. This method features a broad …

Since the initial report in 1975, the Shono oxidation has become a powerful tool to
functionalize the α position of amines, including proline derivatives, by electrochemical …

The CuI‐catalyzed selective α‐alkylation of α‐amino acid and peptide derivatives with 2‐
alkyl‐1, 3‐dioxolanes is reported. This oxidative coupling is distinguished by its site …