Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

The Notch signaling pathway regulates many aspects of cancer biology. Most attention has
been given to its role in the transformed cell. However, it is now clear that cancer …

Flowing blood generates a frictional force called shear stress that has major effects on
vascular function. Branches and bends of arteries are exposed to complex blood flow …

The CNS critically relies on the formation and proper function of its vasculature during
development, adult homeostasis and disease. Angiogenesis—the formation of new blood …

Tumor growth and metastasis rely on tumor vascular network for the adequate supply of
oxygen and nutrients. Tumor angiogenesis relies on a highly complex program of growth …

The tumor microenvironment is a heterogeneous population of cells consisting of the tumor
bulk plus supporting cells. It is becoming increasingly evident that these supporting cells are …

Esophageal squamous cell carcinoma (ESCC) is the sixth most common cause of cancer-
related mortality worldwide, with more than half of them occurred in China. Radiotherapy …

Angiogenesis is a critical process required for tumor progression. Newly formed blood
vessels provide nutrition and oxygen to the tumor contributing to its growth and …

The concept of antiangiogenic therapy in cancer treatment has led to the approval of
different agents, most of them targeting the well known vascular endothelial growth factor …

The heterogeneous breast cancers can be classified into different subtypes according to
their histopathological characteristics and molecular signatures. Foxa1 expression is linked …