One is not enough: understanding and modeling polysubstance use
EA Crummy, TJ O'Neal, BM Baskin… - Frontiers in …, 2020 - frontiersin.org
Substance use disorder (SUD) is a chronic, relapsing disease with a highly multifaceted
pathology that includes (but is not limited to) sensitivity to drug-associated cues, negative …
pathology that includes (but is not limited to) sensitivity to drug-associated cues, negative …
Neurobiological interactions between stress and the endocannabinoid system
Stress affects a constellation of physiological systems in the body and evokes a rapid shift in
many neurobehavioral processes. A growing body of work indicates that the …
many neurobehavioral processes. A growing body of work indicates that the …
Synthetic cannabinoids: epidemiology, pharmacodynamics, and clinical implications
MS Castaneto, DA Gorelick, NA Desrosiers… - Drug and alcohol …, 2014 - Elsevier
Background Synthetic cannabinoids (SC) are a heterogeneous group of compounds
developed to probe the endogenous cannabinoid system or as potential therapeutics …
developed to probe the endogenous cannabinoid system or as potential therapeutics …
The endocannabinoid system and the brain
R Mechoulam, LA Parker - Annual review of psychology, 2013 - annualreviews.org
The psychoactive constituent in cannabis, Δ9-tetrahydrocannabinol (THC), was isolated in
the mid-1960s, but the cannabinoid receptors, CB1 and CB2, and the major endogenous …
the mid-1960s, but the cannabinoid receptors, CB1 and CB2, and the major endogenous …
The endocannabinoid system as an emerging target of pharmacotherapy
The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …
triggered an exponential growth of studies exploring the endocannabinoid system and its …
The molecular logic of endocannabinoid signalling
D Piomelli - Nature Reviews Neuroscience, 2003 - nature.com
The endocannabinoids are a family of lipid messengers that engage the cell surface
receptors that are targeted by Δ9-tetrahydrocannabinol, the active principle in marijuana …
receptors that are targeted by Δ9-tetrahydrocannabinol, the active principle in marijuana …
[HTML][HTML] 2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain
Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key
regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the …
regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the …
Cannabinoids and the endocannabinoid system in reward processing and addiction: from mechanisms to interventions
R Spanagel - Dialogues in clinical neuroscience, 2020 - Taylor & Francis
The last decades have seen a major gain in understanding the action of cannabinoids and
the endocannabinoid system in reward processing and the development of addictive …
the endocannabinoid system in reward processing and the development of addictive …
The reinstatement model of drug relapse: history, methodology and major findings
Rational and objectives. The reinstatement model is currently used in many laboratories to
investigate mechanisms underlying relapse to drug seeking. Here, we review briefly the …
investigate mechanisms underlying relapse to drug seeking. Here, we review briefly the …
Extinction circuits for fear and addiction overlap in prefrontal cortex
J Peters, PW Kalivas, GJ Quirk - Learning & memory, 2009 - learnmem.cshlp.org
Extinction is a form of inhibitory learning that suppresses a previously conditioned response.
Both fear and drug seeking are conditioned responses that can lead to maladaptive …
Both fear and drug seeking are conditioned responses that can lead to maladaptive …