Diabetic nephropathy and gaseous modulators
Diabetic nephropathy (DN) remains the leading cause of vascular morbidity and mortality in
diabetes patients. Despite the progress in understanding the diabetic disease process and …
diabetes patients. Despite the progress in understanding the diabetic disease process and …
Cardiovascular and renal interactions between cyclosporine and NSAIDs: underlying mechanisms and clinical relevance
Cyclosporine, the prototype calcineurin inhibitor, transformed immunosuppressant regimens
and practices post-organ transplantation. Therapeutic uses of cyclosporine branched out to …
and practices post-organ transplantation. Therapeutic uses of cyclosporine branched out to …
Additive renoprotection by pioglitazone and fenofibrate against inflammatory, oxidative and apoptotic manifestations of cisplatin nephrotoxicity: modulation by PPARs
Nephrotoxicity is a major side effect for the antineoplastic drug cisplatin. Here, we employed
pharmacological, biochemical, and molecular studies to investigate the role of peroxisome …
pharmacological, biochemical, and molecular studies to investigate the role of peroxisome …
PPARγ modulates refractive development and form deprivation myopia in Guinea pigs
M Pan, Z Guan, PS Reinach, L Kang, Y Cao… - Experimental eye …, 2021 - Elsevier
Form deprivation myopia (FDM) is characterized by loss of choroidal thickness (ChT),
reduced choroidal blood perfusion (ChBP), and consequently scleral hypoxia. In some …
reduced choroidal blood perfusion (ChBP), and consequently scleral hypoxia. In some …
Celecoxib offsets the negative renal influences of cyclosporine via modulation of the TGF-β1/IL-2/COX-2/endothelin ETB receptor cascade
HM El-Gowelli, MW Helmy, RM Ali… - Toxicology and applied …, 2014 - Elsevier
Endothelin (ET) signaling provokes nephrotoxicity induced by the immunosuppressant drug
cyclosporine A (CSA). We tested the hypotheses that (i): celecoxib, a selective …
cyclosporine A (CSA). We tested the hypotheses that (i): celecoxib, a selective …
Pioglitazone ameliorates methotrexate-induced renal endothelial dysfunction via amending detrimental changes in some antioxidant parameters, systemic cytokines …
Methotrexate (MTX) is widely used in treatment of cancers and autoimmune diseases.
However, nephrotoxicity is one of its most important side effects. The peroxisome proliferator …
However, nephrotoxicity is one of its most important side effects. The peroxisome proliferator …
Interference with AGEs formation and AGEs-induced vascular injury mediates curcumin vascular protection in metabolic syndrome
OAA Ahmed, HM El-Bassossy, AS Azhar… - Scientific Reports, 2020 - nature.com
Vascular dysfunction predisposes to cardiovascular complications of metabolic syndrome
(MetS). The current study investigated the mechanism (s) of curcumin's (CUR) protective …
(MetS). The current study investigated the mechanism (s) of curcumin's (CUR) protective …
Nitric oxide synthase/K+ channel cascade triggers the adenosine A2B receptor-sensitive renal vasodilation in female rats
HM El-Gowelli, SM El-Gowilly, LK Elsalakawy… - European journal of …, 2013 - Elsevier
Adenosine A2B-receptors mediate the adenosine-evoked renal vasodilations in male rats.
Here, we tested whether this finding could be replicated in female renal vasculature and …
Here, we tested whether this finding could be replicated in female renal vasculature and …
Impairment of nitric oxide synthase but not heme oxygenase accounts for baroreflex dysfunction caused by chronic nicotine in female rats
We recently reported that chronic nicotine impairs reflex chronotropic activity in female rats.
Here, we sought evidence to implicate nitric oxide synthase (NOS) and/or heme oxygenase …
Here, we sought evidence to implicate nitric oxide synthase (NOS) and/or heme oxygenase …
[HTML][HTML] Heme oxygenase byproducts variably influences myocardial and autonomic dysfunctions induced by the cyclosporine/diclofenac regimen in female rats
We recently reported that exposure to cyclosporine (CSA) plus diclofenac causes
hypertension and impairs left ventricular (LV) and cardiac autonomic functions in female …
hypertension and impairs left ventricular (LV) and cardiac autonomic functions in female …