Drug-induced gingival overgrowth is a tissue-specific condition and is estimated to affect
approximately one million North Americans. Lesions occur principally as side-effects from …

Gingival overgrowth (GO) is a side effect associated with some distinct classes of drugs,
such as anticonvulsants, immunosuppressant, and calcium channel blockers. GO is …

Human gingiva plays an important role in the maintenance of oral health and shows unique
fetal‐like scarless healing process after wounding. Here we isolate and characterize …

Although it is known that diabetes impairs oral wound healing, relatively little is known about
the cellular parameters affected, particularly in connective tissue. This study investigated the …

Immune suppressed renal transplant patients are more prone to developing oral tissue
alterations due to medications associated with a pleiotropic set of side effects involving the …

Objective: The aim of this manuscript is to describe and analyze the different cellular and
molecular agents involved in the pathogenesis of Drug-induced gingival overgrowth …

Periodontal disease is a prevalent chronic inflammatory condition characterised by an
aberrant host response to a pathogenic plaque biofilm resulting in local tissue damage and …

Cyclosporine is a selective immunosuppressant that has a variety of applications in medical
practice. Like phenytoin and the calcium channel blockers, the drug is associated with …

Few studies have investigated the role of extracellular-matrix proteoglycans in the
pathogenesis of drug-induced gingival overgrowth (DIGO). SPOCK1 is an extracellular …

Cyclosporin A (CsA), an immunosuppressive drug, has overgrowth effects on human
gingival fibroblasts (HGF) in vitro. However, the molecular mechanism responsible for the …