Purpose The hypothalamic–pituitary–adrenal (HPA) axis exerts many actions on the central
nervous system (CNS) aside from stress regulation. Glucocorticoids (GCs) play an important …

Chronic stress is a psychologically significant factor that impairs learning and memory in the
hippocampus. Insulin signaling is important for the development and cognitive function of …

Background: The activity of the Hypothalamic-Pituitary-Adrenal (HPA) axis is commonly
dysregulated in stress-related psychiatric disorders. Annexin A1 (ANXA1), an endogenous …

It is widely accepted that narcotic use during pregnancy and specific environmental factors
(eg, maternal immune activation and chronic stress) may increase risk of neuropsychiatric …

Brain oxidative stress and neuroinflammation have been implicated in various psychiatric
disorders. The current study investigated the effect and mechanism of 25-Methoxyhispidol A …

Many studies indicate that chronic stress and excessive stress hormone can cause an
inflammatory response. Thioredoxin-interacting protein (Txnip) as an endogenous …

Augmentative treatment is considered the best second-option when a first-choice drug has
partial limitations, particularly by allowing antidepressant dose reduction. Considering that …

Objective There is controversy regarding cognitive function in patients with congenital
adrenal hyperplasia (CAH). This study is aimed at the assessment of cognitive functions in …

Background and Purpose Addiction vulnerability involves complex gene X environment
interactions leading to a pathological response to drugs. Identification of the genes involved …

The present study aimed to assess the antioxidative, anti-inflammatory, antiapoptotic, and
anti-depression impacts of Moringa oleifera Lam. leaf ethanolic extract (MOLE) in the …