[HTML][HTML] The gut ecosystem and immune tolerance
T Shao, R Hsu, DL Rafizadeh, L Wang, CL Bowlus… - Journal of …, 2023 - Elsevier
The gastrointestinal tract is home to the largest microbial population in the human body. The
gut microbiota plays significant roles in the development of the gut immune system and has …
gut microbiota plays significant roles in the development of the gut immune system and has …
Inhibition of T-cell activity in alopecia areata: Recent developments and new directions
Alopecia areata (AA) is an autoimmune disease that has a complex underlying
immunopathogenesis characterized by nonscarring hair loss ranging from small bald …
immunopathogenesis characterized by nonscarring hair loss ranging from small bald …
Vaccination with Toxoplasma lysate antigen or its encapsulated niosomes form immunomodulates adjuvant-induced arthritis through JAK3 downregulation
Background Inflammatory autoimmune arthritis like that present in rheumatoid arthritis (RA)
is treated by medications with many side effects. This study was a trial to benefit from …
is treated by medications with many side effects. This study was a trial to benefit from …
Ruxolitinib attenuates microglial inflammatory response by inhibiting NF-κB/MAPK signaling pathway
J Min, H Zheng, H Xia, X Tian, M Liang, J Zhang… - European Journal of …, 2024 - Elsevier
Neuroinflammation is involved in the physiological and pathological processes of numerous
neurological diseases, and its inhibition seems to be a promising therapeutic direction for …
neurological diseases, and its inhibition seems to be a promising therapeutic direction for …
JAK2-mediated phosphorylation of stress-induced phosphoprotein-1 (STIP1) in human cells
Stress-induced phosphoprotein-1 (STIP1)—a heat shock protein (HSP) 70/HSP90 adaptor
protein—is commonly overexpressed in malignant cells, where it controls proliferation via …
protein—is commonly overexpressed in malignant cells, where it controls proliferation via …
[HTML][HTML] Classification of JAK1 inhibitors and SAR research by machine learning methods
Z Yang, Y Tian, Y Kong, Y Zhu, A Yan - Artificial Intelligence in the Life …, 2022 - Elsevier
Abstract Janus kinase 1 (JAK1) is a key regulator of gene transcription, inhibition of JAK1 is
an intervention for many diseases including rheumatoid arthritis and Crohn's disease. In this …
an intervention for many diseases including rheumatoid arthritis and Crohn's disease. In this …
Chicken-Specific Kinome Analysis of Early Host Immune Signaling Pathways in the Cecum of Newly Hatched Chickens Infected With Salmonella enterica Serovar …
Poultry is a major source of human foodborne illness caused by broad host range
Salmonella serovars (paratyphoid), and developing cost-effective, pre-harvest interventions …
Salmonella serovars (paratyphoid), and developing cost-effective, pre-harvest interventions …
Mechanistic Role of Jak3 in Obesity-Associated Cognitive Impairments
Background and Aims: A compromise in intestinal mucosal functions is associated with
several chronic inflammatory diseases. Previously, we reported that obese humans have a …
several chronic inflammatory diseases. Previously, we reported that obese humans have a …
[HTML][HTML] Brain-Gut and Microbiota-Gut-Brain Communication in Type-2 Diabetes Linked Alzheimer's Disease
YS Momen, J Mishra, N Kumar - Nutrients, 2024 - ncbi.nlm.nih.gov
The gastrointestinal (GI) tract, home to the largest microbial population in the human body,
plays a crucial role in overall health through various mechanisms. Recent advancements in …
plays a crucial role in overall health through various mechanisms. Recent advancements in …
Null Function of Npr1 Disturbs Immune Response in Colonic Inflammation During Early Postnatal Stage
C Long, H Liu, W Zhan, L Chen, A Wu, L Yang, S Chen - Inflammation, 2022 - Springer
Abstract Natriuretic peptide receptor 1 (NPR1) is conventionally known as a regulator of
vascular homeostasis. Here, we generated an Npr1 knockout mouse model with …
vascular homeostasis. Here, we generated an Npr1 knockout mouse model with …