Pathological and molecular mechanisms of prostate carcinogenesis: implications for diagnosis, detection, prevention, and treatment

AM De Marzo, TL DeWeese, EA Platz… - Journal of cellular …, 2004 - Wiley Online Library
Prostate cancer is an increasing threat throughout the world. As a result of a demographic
shift in population, the number of men at risk for developing prostate cancer is growing …

A potential therapeutic strategy for prostatic disease by targeting the oral microbiome

C Fang, L Wu, C Zhu, WZ Xie, H Hu… - Medicinal research …, 2021 - Wiley Online Library
Nowadays, human microbiome research is rapidly growing and emerging evidence has
witnessed the critical role that oral microbiome plays in the process of human health and …

Chronic inflammation in benign prostate tissue is associated with high-grade prostate cancer in the placebo arm of the prostate cancer prevention trial

B Gurel, MS Lucia, IM Thompson Jr, PJ Goodman… - … , biomarkers & prevention, 2014 - AACR
Background: Chronic inflammation is hypothesized to influence prostate cancer
development, although a definitive link has not been established. Methods: Prostate cancer …

The influence of chronic inflammation in prostatic carcinogenesis: a 5-year followup study

GT MacLennan, R Eisenberg, RL Fleshman… - The Journal of …, 2006 - auajournals.org
Purpose: We investigated an association between chronic prostatic inflammation and
prostate carcinogenesis. Materials and Methods: Initial prostate needle biopsies from 177 …

Biomarkers of prostatic cancer: an attempt to categorize patients into prostatic carcinoma, benign prostatic hyperplasia, or prostatitis based on serum prostate specific …

S Sarwar, MAM Adil, P Nyamath, M Ishaq - Prostate Cancer, 2017 - Wiley Online Library
Prostatitis, BPH, and P. Ca are the most frequent pathologies of the prostate gland that are
responsible for morbidity in men. Raised levels of PSA are seen in different pathological …

Effect of NIH-IV prostatitis on free and free-to-total PSA

I Stancik, W Lüftenegger, M Klimpfinger, MM Müller… - European urology, 2004 - Elsevier
OBJECTIVE:: To examine the effect of asymptomatic prostatic inflammation (NIH category IV
prostatitis) on total PSA (tPSA), free serum PSA (fPSA) and the ratio of free-to-total prostate …

Association of extent and aggressiveness of inflammation with serum PSA levels and PSA density in asymptomatic patients

E Kandirali, C Boran, E Serin, A Semercioz, A Metin - Urology, 2007 - Elsevier
OBJECTIVES: The relationship between serum prostate-specific antigen (PSA) levels and
histologic prostatic inflammation is controversial. Previous studies were performed using …

Prostatitis and serum prostate-specific antigen

P Sindhwani, CM Wilson - Current urology reports, 2005 - Springer
Prostatitis is an inflammatory condition of the prostate and has been divided into four
categories according to the National Institutes of Health classification. This article reviews …

Chronic inflammation in benign prostatic hyperplasia: implications for therapy

L Wang, J Yang, L Yang, Z Liu - Medical hypotheses, 2008 - Elsevier
Benign prostatic hyperplasia (BPH) is a common age related proliferative abnormality of the
human prostate. Histological features demonstrate that the typical nodules of BPH are …

Intraprostatic inflammation is positively associated with serum PSA in men with PSA< 4 ng ml− 1, normal DRE and negative for prostate cancer

MH Umbehr, B Gurel, TJ Murtola, S Sutcliffe… - Prostate cancer and …, 2015 - nature.com
Background: Biopsies performed for elevated serum PSA often show inflammatory infiltrates.
However, the influence of intraprostatic inflammation on serum PSA in men without biopsy …