I review single-molecule experiments (SMEs) in biological physics. Recent technological
developments have provided the tools to design and build scientific instruments of high …

Atomic force microscopy (AFM) is part of a range of emerging microscopic methods for
biologists which offer the magnification range of both the light and electron microscope, but …

This review's main objective is to discuss some physico-chemical features of
polysaccharides as intrinsic determinants for the supramolecular structures that can …

The atomic force microscope (AFM), a member of the scanning probe family of microscopes,
generates height maps of sample surfaces with subnanometer resolution. Importantly, AFM …

Recent work has highlighted an intimate link between the internal friction of single
biopolymers and dynamics on an underlying energy landscape of conformational change …

In single-molecule mechanics experiments the molecular elasticity is usually measured from
the deformation in response to a controlled applied force, eg, via an atomic force microscope …

The extension of 1–6 polysaccharides has been studied in a series of recent single
molecule AFM experiments. For dextran, a key finding was the existence of a plateau in the …

Biological macromolecules have complex and nontrivial energy landscapes, endowing them
with a unique conformational adaptability and diversity in function. Hence, understanding …

We apply a nanorheology technique to explore the mechanical properties of a globular
protein in the frequency range 10 Hz–10 kHz and find that the folded state of the protein …

For proteins, the mechanical properties of the folded state are directly related to function,
which generally entails conformational motion. Through sub-Angstrom resolution …