Macrophage M1 regulatory diabetic nephropathy is mediated by m6A methylation modification of lncRNA expression

CY Li, F Su, Z Liang, L Zhang, F Liu, WX Fan, Z Li - Molecular Immunology, 2022 - Elsevier
Immune and inflammatory responses have been identified to play an important role in
diabetic nephropathy (DN)(H. Zhou et al.(2021)). It was found that the part of long non …

Identification of ULK1 as a novel mitophagy-related gene in diabetic nephropathy

YY Yang, ZX Gao, ZH Mao, DW Liu, ZS Liu… - Frontiers in …, 2023 - frontiersin.org
Background Accumulating evidence indicates that mitophagy is crucial for the development
of diabetic nephropathy (DN). However, little is known about the key genes involved. The …

Multiple expression assessments of ACE2 and TMPRSS2 SARS-CoV-2 entry molecules in the urinary tract and their associations with clinical manifestations of COVID …

X Ren, S Wang, X Chen, X Wei, G Li… - Infection and Drug …, 2020 - Taylor & Francis
Background Since December 2019, the novel coronavirus, severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), first spread quickly in Wuhan, China, then globally …

Differential urinary proteome analysis for predicting prognosis in type 2 diabetes patients with and without renal dysfunction

HS Ahn, JH Kim, H Jeong, J Yu, J Yeom… - International Journal of …, 2020 - mdpi.com
Renal dysfunction, a major complication of type 2 diabetes, can be predicted from estimated
glomerular filtration rate (eGFR) and protein markers such as albumin concentration. Urinary …

Gene Biomarkers Related to Th17 Cells in Macular Edema of Diabetic Retinopathy: Cutting-Edge Comprehensive Bioinformatics Analysis and In Vivo Validation

J Huang, Q Zhou - Frontiers in Immunology, 2022 - frontiersin.org
Background Previous studies have shown that T-helper 17 (Th17) cell-related cytokines are
significantly increased in the vitreous of proliferative diabetic retinopathy (PDR), suggesting …

Identification and analysis of diverse cell death patterns in diabetic kidney disease using microarray-based transcriptome profiling and single-nucleus RNA …

Y Luo, L Liu, C Zhang - Computers in Biology and Medicine, 2024 - Elsevier
Background Diabetic kidney disease (DKD) is the most lethal complication of diabetes.
Diverse programmed cell death (PCD) has emerged as a crucial disease phenotype that …

Identification of ferroptosis-related genes and pathways in diabetic kidney disease using bioinformatics analysis

D Liu, W Zhou, L Mao, Z Cui, S Jin - Scientific Reports, 2022 - nature.com
Diabetic kidney disease (DKD) is a major public health issue because of its refractory
nature. Ferroptosis is a newly coined programmed cell death characterized by the …

Bioinformatics analysis reveals crosstalk among platelets, immune cells, and the glomerulus that may play an important role in the development of diabetic …

X Yao, H Shen, F Cao, H He, B Li, H Zhang… - Frontiers in …, 2021 - frontiersin.org
Diabetic nephropathy (DN) is the main cause of end stage renal disease (ESRD).
Glomerulus damage is one of the primary pathological changes in DN. To reveal the gene …

Integrated analysis of potential biomarkers associated with diabetic periodontitis development based on bioinformatics: an observational study

Y Wu, YH Xing, S Tao, M Jiao, M Zhu, YT Han, W Guo… - Medicine, 2023 - journals.lww.com
Based on the importance of chronic inflammation in the pathogenesis of periodontitis and
diabetes, the bidirectional relationship between these 2 diseases has been widely …

VEPTP inhibition with an extracellular domain targeting antibody did not restore albuminuria in a mouse model of diabetic kidney disease

R Rana, TA Natoli, P Khandelwal, P Pissios… - Physiological …, 2024 - Wiley Online Library
Diabetic kidney disease (DKD) is the leading cause of end‐stage kidney disease. DKD is a
heterogeneous disease with complex pathophysiology where early endothelial dysfunction …