DNMT3A in haematological malignancies
L Yang, R Rau, MA Goodell - Nature Reviews Cancer, 2015 - nature.com
DNA methylation patterns are disrupted in various malignancies, suggesting a role in the
development of cancer, but genetic aberrations directly linking the DNA methylation …
development of cancer, but genetic aberrations directly linking the DNA methylation …
The role of mutations in epigenetic regulators in myeloid malignancies
AH Shih, O Abdel-Wahab, JP Patel… - Nature Reviews Cancer, 2012 - nature.com
Recent genomic studies have identified novel recurrent somatic mutations in patients with
myeloid malignancies, including myeloproliferative neoplasms (MPNs), myelodysplastic …
myeloid malignancies, including myeloproliferative neoplasms (MPNs), myelodysplastic …
Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability
Background Cytosine DNA methylation is widely described as a transcriptional repressive
mark with the capacity to silence promoters. Epigenome engineering techniques enable …
mark with the capacity to silence promoters. Epigenome engineering techniques enable …
DNMT3A-coordinated splicing governs the stem state switch towards differentiation in embryonic and haematopoietic stem cells
Upon stimulation by extrinsic stimuli, stem cells initiate a programme that enables
differentiation or self-renewal. Disruption of the stem state exit has catastrophic …
differentiation or self-renewal. Disruption of the stem state exit has catastrophic …
[HTML][HTML] DNMT3A Mutations in Acute Myeloid Leukemia
Background The genetic alterations responsible for an adverse outcome in most patients
with acute myeloid leukemia (AML) are unknown. Methods Using massively parallel DNA …
with acute myeloid leukemia (AML) are unknown. Methods Using massively parallel DNA …
[PDF][PDF] The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers
DA Russler-Germain, DH Spencer, MA Young… - Cancer cell, 2014 - cell.com
Somatic mutations in DNMT3A, which encodes a de novo DNA methyltransferase, are found
in∼ 30% of normal karyotype acute myeloid leukemia (AML) cases. Most mutations are …
in∼ 30% of normal karyotype acute myeloid leukemia (AML) cases. Most mutations are …
Structural basis for DNMT3A-mediated de novo DNA methylation
DNA methylation by de novo DNA methyltransferases 3A (DNMT3A) and 3B (DNMT3B) at
cytosines is essential for genome regulation and development,. Dysregulation of this …
cytosines is essential for genome regulation and development,. Dysregulation of this …
Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation
Genetic imprinting, found in flowering plants and placental mammals, uses DNA methylation
to yield gene expression that is dependent on the parent of origin. DNA methyltransferase …
to yield gene expression that is dependent on the parent of origin. DNA methyltransferase …
Cyclical DNA methylation of a transcriptionally active promoter
R Métivier, R Gallais, C Tiffoche, C Le Péron… - Nature, 2008 - nature.com
Processes that regulate gene transcription are directly under the influence of the genome
organization. The epigenome contains additional information that is not brought by DNA …
organization. The epigenome contains additional information that is not brought by DNA …
Allosteric control of mammalian DNA methyltransferases–a new regulatory paradigm
A Jeltsch, RZ Jurkowska - Nucleic acids research, 2016 - academic.oup.com
In mammals, DNA methylation is introduced by the DNMT1, DNMT3A and DNMT3B
methyltransferases, which are all large multi-domain proteins containing a catalytic C …
methyltransferases, which are all large multi-domain proteins containing a catalytic C …